| 卓泽铭,邢 势,王和杰,陈立喜,王 源.脉冲射频术对膝关节骨性关节炎患者膝关节功能及血清IL-7R、TNF-α、IGF水平的影响[J].现代生物医学进展英文版,2021,(13):2551-2554. |
| 脉冲射频术对膝关节骨性关节炎患者膝关节功能及血清IL-7R、TNF-α、IGF水平的影响 |
| Effects of Pulsed Radiofrequency on Knee Joint Function and Serum Levels of IL-7R, TNF-α and IGF in Patients with Osteoarthritis of Knee Joint |
| Received:October 26, 2020 Revised:November 21, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.13.032 |
| 中文关键词: 脉冲射频术 膝关节骨性关节炎 膝关节功能 IL-7R TNF-α IGF |
| 英文关键词: Pulsed radiofrequency Osteoarthritis of knee joint Knee function IL-7R TNF-α IGF |
| 基金项目:海南省自然科学基金项目（817332） |
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| 中文摘要: |
| 摘要 目的：探讨脉冲射频术对膝关节骨性关节炎患者膝关节功能及血清白介素7受体（IL-7R）、肿瘤坏死因子-α（TNF-α）、胰岛素样生长因子（IGF）的影响。方法：选取2018年1月-2020年6月我院接收的90例膝关节骨性关节炎患者，按随机数字表法为观察组和对照组各45例。观察组采用脉冲射频术治疗，对照组采用关节腔内注射玻璃酸钠治疗。观察并比较两组患者的治疗效果、VAS评分、Lysholm膝关节功能评分及血清炎症因子水平。结果：观察组治疗后1个月、3个月的VAS评分低于对照组，Lysholm评分高于对照组（P<0.05），两组患者治疗后6个月的VAS评分和Lysholm评分比较无统计学差异（P>0.05）。观察组在治疗后6个月的优良率为93.33%，与对照组的88.89%比较差异无统计学意义（P>0.05）。治疗后1个月两组患者IL-7R、TNF-α、IGF水平均低于治疗前，且观察组低于对照组（P<0.05）。结论：脉冲射频术和药物注射治疗膝关节骨性关节炎均有较高的疗效，但脉冲射频术的治疗周期更短，更快的缓解患者的疼痛感，提高膝关节功能，降低炎症因子水平，可在临床上作为首选治疗方法加以推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of pulsed radiofrequency on knee joint function and serum interleukin 7 (IL-7), tumor necrosis factor-α(TNF-α) and insulin-like growth factor (IGF) in patients with osteoarthritis of knee joint. Methods: 90 patients with osteoarthritis of knee joint in our hospital from January 2018 to June 2020 were selected and randomly divided into observation group and control group, 45 cases in each group. The observation group was treated with pulse radiofrequency, and the control group was treated with sodium hyaluronate injection in the articular cavity. The treatment effect, VAS score, Lysholm knee joint function score and serum inflammatory factor were observed and compared between the two groups. Results: The VAS score of the observation group at 1 month and 3 months after treatment was lower than that of the control group, and the Lysholm score was higher than that of the control group (P<0.05). There was no significant difference in VAS score and Lysholm score between the two groups at 6 months after treatment (P>0.05). The excellent rate in the observation group was 93.33% after 6 months of treatment, and there was no significant difference compared with 88.89% of the control group(P>0.05). 1 months after treatment,the levels of IL-7R, TNF-α and IGF in the two groups were all lower than before treatment, and the observation group was lower than that in the control group(P<0.05). Conclusion: The efficacy of pulsed radiofrequency and drug injection in the treatment of osteoarthritis of the knee are higher, but shorter treatment cycles of pulsed radiofrequency, faster to ease the pain of patients, improve knee function, decrease the level of inflammatory factors,which can be used as the preferred method of treatment in clinical application. |
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