| 万 明,金 宇,叶 昱,王家丽,高 原.芪药消渴胶囊联合吡格列酮对2型糖尿病患者糖脂代谢和肝肾功能的影响[J].现代生物医学进展英文版,2021,(13):2539-2542. |
| 芪药消渴胶囊联合吡格列酮对2型糖尿病患者糖脂代谢和肝肾功能的影响 |
| Effects of Qiyao Xiaoke Capsule Combined with Pioglitazone on Glucose and Lipid Metabolism and Liver and Kidney Function in Patients with Type 2 Diabetes Mellitus |
| Received:January 03, 2021 Revised:January 26, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.13.029 |
| 中文关键词: 芪药消渴胶囊 吡格列酮 2型糖尿病 糖代谢 脂代谢 肝功能 肾功能 |
| 英文关键词: Qiyao Xiaoke capsule Pioglitazone Type 2 diabetes mellitus Glucose metabolism Lipid metabolism Liver function Kidney function |
| 基金项目:四川省科技厅科研基金资助项目（2013JY0112） |
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| 中文摘要: |
| 摘要 目的：探讨芪药消渴胶囊联合吡格列酮对2型糖尿病（T2DM）患者糖脂代谢和肝肾功能的影响。方法：选取2017年1月~2019年12月期间我院收治的98例T2DM患者，随机分为对照组49例（吡格列酮治疗）和联合组49例（芪药消渴胶囊联合吡格列酮治疗），两组均治疗8周，对比两组患者疗效、糖脂代谢指标[甘油三酯（TG）、空腹血糖（FPG）、总胆固醇（TC）、糖化血红蛋白（HbA1c）、高密度脂蛋白（HDL-C）、餐后2 h血糖（2hPG）、低密度脂蛋白（LDL-C）]和肝肾功能指标[谷草转氨酶（AST）、谷丙转氨酶(ALT)、尿素氮（BUN）和肌酐（Scr）]及不良反应。结果：对照组、联合组治疗8周后的临床总有效率分别为81.63%（40/49）、95.92%（47/49），联合组的总有效率高于对照组（P<0.05）。两组治疗后血清AST、ALT与治疗前比较差异均无统计学意义（P>0.05），两组治疗后HDL-C 较治疗前升高，且联合组高于对照组（P<0.05），FPG、2hPG、HbA1c及血清BUN、Scr、TC、TG、LDL-C均较治疗前下降，且联合组低于对照组（P<0.05）。两组不良反应发生率相比无差异（P>0.05）。结论：芪药消渴胶囊联合吡格列酮治疗T2DM患者疗效显著，可有效纠正患者脂代谢紊乱，控制血糖，改善肾功能，对人体肝功能损害轻，安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Qiyao Xiaoke capsule combined with pioglitazone on glucose and lipid metabolism and liver and kidney function in patients with type 2 diabetes mellitus(T2DM). Methods: 98 patients with T2DM who were admitted in our hospital from January 2017 to December 2019 were selected, the patients were randomly divided into 49 cases in control group （pioglitazone treatment）and 49 cases in combination group（Qiyao Xiaoke capsule combined with pioglitazone treatment）, after 8 weeks of treatment, the curative effect, glycolipid metabolism indexes [triglyceride (TG), fasting blood glucose (FPG), total cholesterol (TC), glycosylated hemoglobin (HbA1c), high density lipoprotein (HDL-C), 2-hour postprandial blood glucose(2hPG), low density lipoprotein (LDL-C)] and liver and kidney function [aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (BUN) and creatinine (Scr)] indexes and adverse reactions were compared between the two groups. Results: The total effective rates of the control group, the combination group were 71.43% (40/49), 93.88% (47/49) after 8 weeks of treatment, and the total effective rate of the combination group was higher than that of the control group(P<0.05). There was no significant difference in AST, ALT between the two groups after treatment compared with before treatment(P>0.05), HDL-C in the two groups increase compared with before treatment, and the combination group was higher than the control group(P<0.05), FPG, 2hPG, HbA1c and serum BUN, Scr, TC, TG, LDL-C decreased after treatment compared with those of before treatment, and the combination group was lower than the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Qiyao Xiaoke capsule combined with pioglitazone in the treatment of T2DM patients, can effectively control blood sugar, correct lipid metabolism disorder, improve kidney function, and have slight damage to human liver function. |
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