| 曾 聪,赵 健,吴 静,刘晶晶,宋晓峰.蛋白质组氨酸磷酸化研究进展[J].现代生物医学进展英文版,2021,(12):2396-2400. |
| 蛋白质组氨酸磷酸化研究进展 |
| Review on Histidine Phosphorylation in Protein |
| Received:May 30, 2020 Revised:June 26, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.12.043 |
| 中文关键词: 蛋白质磷酸化 组氨酸磷酸化 激酶 磷酸酶 |
| 英文关键词: Protein phosphorylation Histidine phosphorylation Kinase Phosphatase |
| 基金项目:国家自然科学基金项目（61973155）；中国博士后科学基金项目（2019M661817） |
|
| Hits: 666 |
| Download times: 766 |
| 中文摘要: |
| 摘要：蛋白质磷酸化是一种可逆的翻译后修饰，这种翻译后修饰可以改变蛋白质的构象，进而使蛋白质活化或者失活。组氨酸磷酸化在细胞信号传导过程中发挥着重要作用，且组氨酸磷酸化与人类某些疾病密切相关，然而，由于组氨酸磷酸化含有P-N键，具备不稳定性，有关于组氨酸磷酸化的报道远远少于其它磷酸化的报道。本综述系统的总结了组氨酸磷酸化在生物学过程中的作用，以及近些年取得的重要研究进展，以期对深入研究组氨酸磷酸化提供理论参考。 |
| 英文摘要: |
| ABSTRACT: As a reversible posttranslational modification, phosphorylation can modulate the protein's activity through altering its conformation. Histidine phosphorylation plays a key role in signal transduction and is frequently involved in various human diseases. Due to the lability of the phosphoramidate (P-N) bond of phosphohistidine, histidine phosphorylation is still difficult to detect and has only been reported by a relative handful of studies, which is much less than other phosphorylation modification. In this article, we review the advance of studies on the histidine phosphorylation in recent years and summary its biological functions, which can provide theoretical support for further research. |
|
View Full Text
View/Add Comment Download reader |
| Close |
