| 王燕飞,许园博,王燕星,张润萍,李玉琴.肺炎3号联合金银花治疗儿童肺炎对患儿呼吸功能和炎症反应水平影响[J].现代生物医学进展英文版,2021,(12):2231-2234. |
| 肺炎3号联合金银花治疗儿童肺炎对患儿呼吸功能和炎症反应水平影响 |
| Effect of Pneumonia 3 Combined with Honeysuckle on Children's Pneumonia on Respiratory Function and Inflammation |
| Received:October 26, 2020 Revised:November 22, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.12.029 |
| 中文关键词: 肺炎3号 金银花 儿童肺炎 呼吸功能 炎症反应 |
| 英文关键词: Pneumonia No. 3 Honeysuckle Children's pneumonia Respiratory function Inflammatory response |
| 基金项目:河北省科技计划项目（15277279D） |
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| 中文摘要: |
| 摘要 目的：探讨肺炎3号联合金银花治疗儿童肺炎对患儿呼吸功能和炎症反应水平影响。方法：选取我院2017年2月-2019年4月期间收治的80例肺炎患儿，随机分成对照组和观察组，每组40例，对照组患儿采取阿奇霉素治疗，观察组患儿采取肺炎3号联合金银花治疗，对比不同治疗方法对患儿呼吸功能和炎症反应水平影响。结果：两组患儿治疗前用力肺活量（forced vital capacity，FVC）、第1秒用力呼气容积（orced expiratory volume in 1 second，FEV1）、用力呼气峰流速(expiratory peak flow rate，PEF)对比无统计学差异（P＞0.05），治疗后，观察组患儿上述肺功能指标均明显高于对照组（P＜0.05）。两组治疗前患儿血清肿瘤坏死因子（tumor necrosis factor-α，TNF-α）、白介素（interleukin，IL）-6、IL-10对比无统计学差异（P＞0.05），治疗后，观察组患儿TNF-α、IL-6均明显低于对照组，且观察组IL-10明显高于对照组（P＜0.05）。患儿啰音消失时间、止咳时间、气促消失时间、热退时间以及住院时间对比发现对照组明显长于观察组（P＜0.05）。在治疗总效率方面，观察组明显更高（P＜0.05）。结论：儿童肺炎采取肺炎3号联合金银花治疗效果确切，可明显改善患儿呼吸功能，抑制机体炎性细胞因子，有效改善患儿临床症状，具有一定临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of pneumonia 3 combined with honeysuckle in the treatment of childhood pneumonia on the respiratory function and inflammation of children. Methods: Eighty children with pneumonia admitted in our hospital from February 2017 to April 2019 were randomly divided into a control group and an observation group. Each group had 40 cases. The control group was treated with azithromycin and the observation group was treated with pneumonia. Combined with honeysuckle treatment, No. 3 compares the effects of different treatment methods on the respiratory function and inflammation of children. Results: There was no significant difference between the two groups of children before treatment with forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and forced expiratory peak flow rate (PEF) (P>0.05). After treatment, the observation group had The above lung function indexes of the children were significantly higher than the control group (P<0.05), serum tumor necrosis factor (TNF-α), IL-6, IL-10 in the two groups before treatment There was no statistical difference in comparison(P>0.05). After treatment, the TNF-α and IL-6 of the observation group were significantly lower than the control group, and the observation group IL-10 was significantly higher than the control group (P<0.05). The disappearance time of rales, coughing time, disappearance of shortness of breath, shortness of heat, and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05). The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05). Conclusion: Pneumonia No. 3 combined with honeysuckle treatment is effective in children with pneumonia. It can significantly improve the respiratory function of children, suppress the body's inflammatory cytokines, and effectively improve the clinical symptoms of children. It has certain clinical significance. |
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