| 秦 艳,张万平,张海鹰,张 鹏,马世军.羟考酮和舒芬太尼对丙泊酚靶控输注时患者意识消失和BIS的影响[J].现代生物医学进展英文版,2021,(12):2237-2230. |
| 羟考酮和舒芬太尼对丙泊酚靶控输注时患者意识消失和BIS的影响 |
| Effects of Oxycodone and Sufentanil on Patients' Loss of Consciousness and BIS during Target-controlled Infusion of Propofol |
| Received:October 25, 2020 Revised:November 21, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.12.028 |
| 中文关键词: 羟考酮 舒芬太尼 丙泊酚 意识消失 BIS |
| 英文关键词: Oxycodone Sufentanil Propofol Loss of consciousness BIS |
| 基金项目:国家自然科学基金项目(81273902) |
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| 中文摘要: |
| 摘要 目的：采用羟考酮和舒芬太尼复合丙泊酚对患者进行TCI全麻诱导，考察对OAA/S和脑电双频谱指数（Bispectral index，BIS）的影响。方法：以2017年3月-2020年2月于我院行全麻插管手术的80患者为研究对象，采用随机数字表法分为对照组和研究组，各40例，对照组进行舒芬太尼联合丙泊酚TCI麻醉，研究组进行羟考酮联合丙泊酚TCI麻醉，考察不同丙泊酚Ce（0~2.5 μg/mL）时OAA/S值、不同时间（基础值、TCI开始前、患者意识消失时）BIS值、诱导持续时间以及意识消失时丙泊酚Ce浓度。结果：在丙泊酚Ce为0.5、1.0 μg/mL时，研究组OAA/S值显著高于对照组（P＜0.05），在其他浓度下两组OAA/S值无显著差异（P＞0.05）；与0 μg/mL时的OAA/S相比，两组0.5~2.5 μg/mL时的OAA/S均显著降低（P＜0.05）。两组患者BIS基础值、TCI开始前和患者意识消失时的BIS值均无显著差异（P＞0.05）。两组患者诱导持续时间和意识消失时Ce均无明显差异（P＞0.05）。结论：羟考酮、舒芬太尼复合丙泊酚靶控麻醉诱导，均能引起OAA/S和 BIS值的降低，可增强丙泊酚镇静催眠作用，具有一定的协同作用。 |
| 英文摘要: |
| ABSTRACT Objective: Oxycodone and sufentanil combined with propofol were used to induce TCI general anesthesia in patients to investigate the effects on OAA/S and bispectral index(BIS). Methods: A total of 80 patients, who underwent general anesthesia intubation in Second Affiliated Hospital of Xi'an Medical College from March 2017 to February 2020, were chosen as the research subjects and were randomly divided into control group(n=40) and research group(n=40). The control group were given sufentanil combined with propofol TCI anesthesia, and the study group were given oxycodone combined with propofol TCI anesthesia. The OAA/S value of different propofol Ce (0~2.5 μg/mL), the BIS value at different time (basic value, before the start of TCI, when the patient's consciousness disappeared), the duration of induction, and the concentration of propofol Ce when consciousness disappeared were studied. Results: When propofol Ce was 0.5 and 1.0 μg/mL, the OAA/S value of the study group was significantly higher than that of the control group (P<0.05), and there was no significant difference in the OAA/S value between the two groups at other concentrations(P>0.05). Compared with the OAA/S at 0 μg/mL, the OAA/S at 0.5~2.5 μg/mL in the two groups were significantly lower(P<0.05). There was no significant difference in the basic BIS value, the BIS value before the start of TCI and when the patient's consciousness disappeared between the two groups(P>0.05). There was no significant difference in the duration of induction and Ce when consciousness disappeared between the two groups(P>0.05). Conclusion: Oxycodone, sufentanil combined with propofol target-controlled anesthesia induction can all cause the decrease of OAA/S and BIS values and can enhance the sedative and hypnotic effects of propofol, with a certain synergistic effect. |
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