| 李昌盛,孙临奥,周雪峰,张德明,程尼涛.胞质分裂作用因子10在肺癌诊断及预后中的意义[J].现代生物医学进展英文版,2021,(12):2258-2262. |
| 胞质分裂作用因子10在肺癌诊断及预后中的意义 |
| Significance of Dedicator of Cytokinesis 10 in Diagnosis and Prognosis of Lung Cancer |
| Received:January 08, 2021 Revised:January 30, 2021 |
| DOI：10.13241/j.cnki.pmb.2021.12.013 |
| 中文关键词: 胞质分裂作用因子10 诊断 预后 肺癌 影响因素 |
| 英文关键词: Dedicator of cytokinesis 10 Diagnosis Prognosis Lung cancer Influencing factors |
| 基金项目:湖北省科技计划项目（2017CFB635） |
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| 中文摘要: |
| 摘要 目的：探讨胞质分裂作用因子10（Dock10）在肺癌组织及癌旁组织中的表达及其在肺癌预后及诊断中的意义。方法：选取2010年6月至2015年6月期间我院收治的肺癌患者98例，检测其肺癌组织及癌旁组织中Dock10的表达情况。分析Dock10表达与患者临床病理特征的关系。分析患者预后的影响因素。分析Dock10在肺癌诊断中的价值及其表达与患者预后的关系。结果：肺癌组织中Dock10 mRNA及蛋白表达水平、平均表达量均高于癌旁组织（P<0.05）。Dock10表达与肿瘤大小、TNM分期、分化程度有关（P<0.05）。COX比例风险回归分析结果显示，吸烟史、TNM分期、分化程度、Dock10表达均为肺癌患者预后的影响因素（P<0.05）。受试者工作特征（ROC）曲线分析结果显示Dock10诊断肺癌的曲线下面积及最佳诊断临界值分别为0.894、1.877 ng/mL，具有一定诊断价值。Dock10低表达患者的5年生存率高于Dock10高表达患者（P<0.05）。结论：Dock10对肺癌的临床诊断和预后具有一定意义，可能作为一种潜在的肺癌诊断和预后评估辅助指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of dedicator of cytokinesis 10 (Dock10) in lung cancer tissues and adjacent tissues and its significance in the prognosis and diagnosis of lung cancer. Methods: 98 patients with lung cancer in our hospital from June 2010 to June 2015 were selected, and the expression of Dock10 in lung cancer tissues and adjacent tissues were detected. The relationship between the expression of Dock10 and clinicopathological features was analyzed. The influencing factors of prognosis were analyzed. The value of Dock10 in the diagnosis of lung cancer and the relationship between its expression and prognosis were analyzed. Results: The expression levels and average expression quantity of Dock10 mRNA and protein in lung cancer tissues were higher than those in adjacent tissues(P<0.05). The expression of Dock10 was correlated with tumor size, TNM stage and degree differentiation (P<0.05). Cox proportional hazards regression analysis showed that smoking history, TNM stage, differentiation degree and expression of Dock10 were the influencing factors for the prognosis of patients with lung cancer(P<0.05). The results of receiver operating characteristic (ROC) curve analysis showed that the area under the curve and the optimal critical value of Dock 10 for diagnosis of lung cancer were 0.894 and 1.877 ng/mL, respectively, which had certain diagnostic value. The 5-year survival rate of patients with low expression of Dock10 was higher than that of patients with high expression of Dock10(P<0.05). Conclusion: Dock10 has a certain significance in the clinical diagnosis and prognosis of lung cancer, and may be used as a potential auxiliary index for the diagnosis and prognosis of lung cancer. |
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