| 董锦秀,方玉明,周红娟,张志飞,夏正新.中性粒细胞绝对值对脓毒血症并发肾损伤的早期诊断[J].现代生物医学进展英文版,2021,(12):2249-2252. |
| 中性粒细胞绝对值对脓毒血症并发肾损伤的早期诊断 |
| Application of Absolute Value of Neutrophils in Early Diagnosis of Sepsis Combined with Renal Injury |
| Received:November 03, 2020 Revised:November 26, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.12.011 |
| 中文关键词: 中性粒细胞绝对值 脓毒血症 肾损伤 诊断 急性生理和慢性健康评分Ⅱ 序贯多器官功能障碍评分 |
| 英文关键词: Neutrophil absolute value Sepsis Kidney injury Diagnosis Acute physiology and chronic health score Ⅱ Sequential multiple organ dysfunction score |
| 基金项目:国家自然科学基金面上项目（31170828，31370884） |
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| 中文摘要: |
| 摘要 目的：探讨中性粒细胞绝对值对脓毒血症并发肾损伤的早期诊断价值。方法：2016年1月-2020年6月选择在本院重点监护病房(Intensive care unit，ICU)和急诊科进行诊治的脓毒血症患者145例，测定与计算患者的中性粒细胞绝对值，调查患者的临床资料并进行早期诊断分析。结果：在145例患者中，发生肾损伤69例(肾损伤组)，发生率为47.6 %。肾损伤组的年龄、性别、白细胞计数(white blood cell，WBC)计数、C反应蛋白(C reactive protein，CRP)、降钙素原(procalcitonin，PCT)、体重指数等与非肾损伤组对比差异无统计学意义(P>0.05)。肾损伤组的肌酐(Serum creatinine，Scr)和尿素氮(Blood urea nitrogen，BUN)、急性生理和慢性健康评分Ⅱ(acute physiology and chronic health evaluation II，APACHE Ⅱ)评分、序贯多器官功能障碍评分(sequential organ failure assessment，SOFA)都显著高于非肾损伤组(P<0.05)。肾损伤组的中性粒细胞绝对值都显著高于非损伤组(P<0.05)。logistic回归分析显示中性粒细胞绝对值、BUN、Scr、APACHE Ⅱ评分、SOFA评分都为影响肾损伤发生的主要独立因素(P<0.05)。结论：脓毒血症患者多伴随有肾损伤，可导致中性粒细胞绝对值升高，中性粒细胞绝对值也是导致脓毒血症并发肾损伤的主要因素，也具有重要的诊断价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the values of absolute neutrophils in the early diagnosis of sepsis with renal injury. Methods: A total of 145 patients with sepsis,who were diagnosed and treated in the Intensive Care Unit (ICU) and Emergency departments of our hospital from January 2016 to June 2020, were selected. The absolute values of neutrophils of the patients were detected and calculated, and clinical data and early diagnosis were recorded. Results: There were 69 cases of renal injury (kidney injury group) in 145 cases, the incidence was 47.6 %. There were not statistical significance in the age, gender, WBC count, CRP, PCT, body mass index, etc. between the kidney injury group and the non-kidney injury group (P>0.05). The Scr and BUN, APACHE Ⅱ scores, SOFA scores in the kidney injury group were significantly higher than those in the non-kidney injury group(P<0.05). The absolute values of neutrophils in the kidney injury group were significantly higher than those in the non-injury group(P<0.05). Logistic regression analysis showed that the absolute value of neutrophils, BUN, Scr, APACHE Ⅱ score, and SOFA score were the main independent factors affecting the occurrence of kidney injury(P<0.05). Conclusion: Patients with sepsis are mostly accompanied by renal injury, which can lead to increase of the absolute value of neutrophils. The absolute value of neutrophils is also the main factor leading to sepsis with renal injury, with good diagnostic value. |
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