| 孟 锐,魏玉杰,董建增,易 忠,王恩宁.复方丹参滴丸联合沙库巴曲缬沙坦对老年心肌梗死患者PCI术后炎性反应、心室重塑和心肌灌注的影响[J].现代生物医学进展英文版,2021,(11):2159-2163. |
| 复方丹参滴丸联合沙库巴曲缬沙坦对老年心肌梗死患者PCI术后炎性反应、心室重塑和心肌灌注的影响 |
| Effects of Compound Danshen Dripping Pills Combined with Sarkubatrovalsartan on Elderly Patients with Myocardial Infarction after PCI |
| Received:October 28, 2020 Revised:November 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.11.035 |
| 中文关键词: 急性心肌梗死 PCI手术 复方丹参滴丸 沙库巴曲缬沙坦 老年 炎性因子 心室重塑 心肌灌注 |
| 英文关键词: Acute myocardial infarction PCI operation Compound Danshen dripping pills Sakubatravalsartan Elderly inflammatory factors Ventricular remodeling Myocardial perfusion |
| 基金项目:国家自然科学基金项目（81370315） |
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| 中文摘要: |
| 摘要 目的：探讨复方丹参滴丸联合沙库巴曲缬沙坦对老年心肌梗死患者经皮冠状动脉介入术（percutaneous coronary intervention，PCI）术后炎性反应、心室重塑和心肌灌注的影响。方法：采用随机数字表法将本院2017年3月至2020年2月间收治的行PCI治疗的68例老年心肌梗死为研究对象，分为对照组（34例）和观察组（34例）。两组均行常规药物治疗，在此基础上予以对照组沙库巴曲缬沙坦治疗，予以观察组复方丹参滴丸联合沙库巴曲缬沙坦治疗。比较两组治疗前后血浆中超敏C反应蛋白（high-sensitivity creactive protein，hs-CRP)、肿瘤坏死因子-α（Tumor necrosis factor-α，TNF-α）、白细胞介素-8（interleukin-8，IL-8）、N末端脑钠肽前体（N-terminal-pro-brain-natriuretic-peptide，NT-proBNP）、左室舒张末期前后径（left ventricular end-diastolic diamete，LVEDD）、左室射血分数（left ventricular ejection fraction，LVEF）、左室质量指数（left ventricular mass index，LVMI）以及治疗后TIMI血流分级。结果：两组血浆hs-CRP、TNF-α、IL-8和NT-proBNP水平以及LVEDD和LVMI水平较治疗前明显降低，LVEF水平明显增加（P<0.05）。观察组治疗后血浆hs-CRP、TNF-α、IL-8和NT-proBNP水平以及LVEDD和LVMI水平明显低于对照组，LVEF水平明显高于对照组（P<0.05）。两组术后20 minTIMI血流分级均明显好转，观察组术后20 min时TIMI血流分级明显优于对照组（P<0.05）。两组不良反应总发生率比较无明显差异（P>0.05）。结论：复方丹参滴丸联合沙库巴曲缬沙坦能够明显降低老年心肌梗死患者PCI术后炎性反应，抑制心室重塑，改善心肌灌注，安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Compound Danshen dripping pills combined with sarkubatrovalsartan on inflammatory response, ventricular remodeling and myocardial perfusion after percutaneous coronary intervention (PCI) in elderly patients with myocardial infarction. Methods: A total of 68 elderly patients with myocardial infarction, who were treated with PCI in Aerospace Central Hospital from March 2017 to February 2020, were chosen as research subjects and randomly divided into control group(n=34) and observation group(n=34). The two groups were treated with conventional drug therapy, on the basis of which, the patients in the control group were treated with sakubatravalsartan, and the patients in the observation group were treated with Compound Danshen dripping pills combined with sarkubatrovalsartan. The plasma levels of high-sensitivity Creactive protein (hs CRP), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), N-terminal pro brain natriuretic peptide (NT proBNP), left ventricular end-diastolic diamete (LVEDD), left ventricular ejection fraction (LVEF), and left ventricular mass index (LVMI) were compared between the two groups before and after treatment; TIMI blood flow classification and ST segment depression after treatment were analyzed. Results: The levels of hs CRP, TNF-α, IL-8, NT-proBNP, LVEDD and LVMI of the two groups were significantly lower than those before treatment, and LVEF levels were significantly increased (P<0.05). After treatment, the plasma levels of hs CRP, TNF-α, IL-8, NT-proBNP, LVEDd and LVMI of the observation group were significantly lower than these of the control group, and the LVEF level was significantly higher than that in the control group (P<0.05). The TIMI blood flow classification of the two groups was significantly improved 20 min after operation, and the TIMI blood flow classification of the observation group was significantly better than that of the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P >0.05). Conclusion: Compound Danshen dripping pills combined with sakubatrovalsartan can significantly reduce the inflammatory reaction, inhibit ventricular remodeling and improve myocardial perfusion in elderly patients with myocardial infarction. |
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