| 刘英香,王丽辉,李晓惠,韦喜生,唐育群,郑晓君.鼻咽癌组织COX-2、SDHB、HSP90β表达与临床病理特征及预后的关系研究[J].现代生物医学进展英文版,2021,(10):1921-1925. |
| 鼻咽癌组织COX-2、SDHB、HSP90β表达与临床病理特征及预后的关系研究 |
| Study on the Relationship between the Expression of COX-2, SDHB and HSP90β and the Clinicopathological Characteristics and Prognosis of Nasopharyngeal Carcinoma |
| Received:July 23, 2020 Revised:August 17, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.10.025 |
| 中文关键词: 鼻咽癌 环氧化酶-2 琥珀酸脱氢酶 热休克蛋白90β 临床病理特征 预后 |
| 英文关键词: Nasopharyngeal carcinoma Cyclooxygenase-2 Succinate dehydrogenase Heat shock protein 90β Clinicopathological features Prognosis |
| 基金项目:广东省自然科学基金项目（2014A030313780） |
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| 中文摘要: |
| 摘要 目的：探讨鼻咽癌组织环氧化酶-2（COX-2）、琥珀酸脱氢酶（SDHB）、热休克蛋白90β（HSP90β）表达与临床病理特征及预后的关系。方法：应用免疫组织化学染色法对78例鼻咽癌组织和65例鼻咽部慢性炎症组织中COX-2、SDHB、HSP90β表达情况进行检测，并分析鼻咽癌组织中COX-2、SDHB、HSP90β表达与临床病理特征的关系及其相关性。所有患者随访3年，根据不同COX-2、SDHB、HSP90β表达情况将患者分为COX-2阳性组、COX-2阴性组、SDHB阳性组、SDHB阴性组、HSP90β阳性组、HSP90β阴性组，比较各组患者生存情况。结果：鼻咽癌组织中COX-2、HSP90β阳性率显著高于鼻咽部慢性炎症组织，SDHB阳性率显著低于鼻咽部慢性炎症组织（P<0.05）。TNM分期为III+IV期、中低分化、有颈淋巴结转移者鼻咽癌组织中COX-2、HSP90β阳性率显著高于TNM分期为I+II期、高分化、无颈淋巴结转移者，SDHB阳性率显著低于TNM分期为I+II期、高分化、无颈淋巴结转移者（P<0.05）。Spearman相关分析显示，鼻咽癌组织中COX-2表达与SDHB表达呈负相关（rs=-0.462, P=0.008），与HSP90β表达呈正相关（rs=0.501, P=0.000），HSP90?茁表达与SDHB表达呈负相关（rs=-0.438, P=0.012）。随访3年，存活49例，死亡29例，存活率62.82%。鼻咽癌组织COX-2阴性组、SDHB阳性组、HSP90β阴性组患者生存率、中位生存期显著优于COX-2阳性组、SDHB阴性组、HSP90β阳性组患者（P<0.05）。结论：鼻咽癌组织中COX-2、SDHB、HSP90β表达情况与患者TNM分期、肿瘤分化情况和颈淋巴结转移相关，且其表达情况与鼻咽癌患者生存期有密切关系。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of cyclooxygenase-2 (COX-2), succinate dehydrogenase (SDHB), heat shock protein 90β (HSP90β) and the clinicopathological characteristics and prognosis of nasopharyngeal carcinoma. Methods: The expression of COX-2, SDHB and HSP90β in 78 cases of nasopharyngeal carcinoma tissue and 65 cases of chronic inflammation of nasopharynx were detected by immunohistochemistry, and the relationship between the expression of COX-2, SDHB and HSP90β and the clinicopathological characteristics of NPC was analyzed. All patients were followed up for 3 years. According to the expression of COX-2, SDHB and HSP90β, the patients were divided into COX-2 positive group, COX-2 negative group, SDHB positive group, SDHB negative group, HSP90β positive group and HSP90β negative group. Results: The positive rate of COX-2 and HSP90β in nasopharyngeal carcinoma tissue was significantly higher than that in nasopharynx, and the positive rate of SDHB was significantly lower than that in nasopharynx (P<0.05). The positive rates of COX-2 and HSP90β in nasopharyngeal carcinoma tissue with TNM stage III+IV, middle and low differentiation and cervical lymph node metastasis were significantly higher than those TNM stage I+II, high differentiation and no cervical lymph node metastasis, and the positive rates of SDHB were significantly lower than those in nasopharyngeal carcinoma tissue with TNM stage I + II, high differentiation and no cervical lymph node metastasis (P<0.05). Spearman correlation analysis showed that COX-2 expression was negatively correlated with SDHB expression (rs=-0.462, P=0.008), positively correlated with HSP90β expression (rs=0.501, P=0.000), and SDHB was negatively correlated with HSP90β expression (rs=-0.438, P=0.012). After 3 years follow-up, 49 cases survived and 29 died, with a survival rate of 62.82%. The survival rate and median survival time of patients in COX-2 negative group, SDHB positive group and HSP90β negative group were significantly better than those in COX-2 positive group, SDHB negative group and HSP90β positive group (P<0.05). Conclusion: The expression of COX-2, SDHB and Hsp90β in NPC is related to TNM stage, tumor differentiation and cervical lymph node metastasis, and its expression is closely related to the survival period of NPC patients. |
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