| 母 蕾,肖 梅,梁 戎,梁 琨,王 鑫.高压氧联合叶酸治疗老年脑小血管病患者认知功能及血浆Hcy变化研究[J].现代生物医学进展英文版,2021,(10):1889-1892. |
| 高压氧联合叶酸治疗老年脑小血管病患者认知功能及血浆Hcy变化研究 |
| Effects of Hyperbaric Oxygen Combined with Folic Acid on Cognitive Function and Plasma Hcy in Elderly Patients with Cerebrovascular Disease |
| Received:August 05, 2020 Revised:August 28, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.10.018 |
| 中文关键词: 高压氧 叶酸 老年脑小血管病 血浆Hcy 认知功能 |
| 英文关键词: Hyperbaric oxygen Folic acid Senile cerebrovascular disease Plasma Hcy Cognitive function |
| 基金项目:内蒙古自治区自然科学基金项目（2017MS（LH）0851） |
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| 中文摘要: |
| 摘要 目的：研究高压氧联合叶酸治疗老年脑小血管病患者认知功能及血浆Hcy变化。方法：选取2019年1月~2020年6月我院收治的80例老年脑小血管病患者作为研究对象，随机将其分为两组，对照组50例，给予叶酸治疗，研究组30例，给予高压氧联合叶酸治疗，观察两组患者治疗后的疗效、认知功能、血浆Hcy水平、生活质量及不良反应。结果：治疗前，两组的蒙特利尔认知评估量表(Montreal Cognitive Assessment，MoCA)认知功能评分、血浆Hcy水平、日常生活能力量表(Activity of Daily Living Scale，ADL)评分对比无差异（P>0.05），治疗后两组的MoCA认知功能评分、ADL评分均升高，血浆Hcy水平均降低，且观察组变化优于对照组( P<0.05)；治疗期间对照组不良反应发生情况为13.33 %，观察组不良反应发生情况为16.00 %，两组对比差异无统计学意义（P>0.05）；研究组总有效率显著高于对照组（93.33 % vs.74.00 %，P<0.05）。结论：高压氧联合叶酸治疗老年脑小血管病患者疗效显著，能显著改善患者的认知功能和Hcy水平，提高其日常生活能力，且安全性高，值得临床应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the changes of cognitive function and plasma Hcy in elderly patients with cerebrovascular disease treated by hyperbaric oxygen and folic acid. Methods: Eighty elderly patients with cerebrovascular disease,who were admitted to Inner Mongolia People's Hospital Geriatrics Center from January 2019 to June 2020, were chosen as the research subjects and were randomly divided into two groups. The control group(n=50) was given folic acid treatment; The study group(n=30) was given high pressure Oxygen combined with folic acid. The efficacy, cognitive function, plasma Hcy level, quality of life and adverse reactions of the two groups were observed after treatment. Results: Before treatment, there was no difference in MoCA cognitive function score, plasma Hcy level, and ability of daily living (ADL) score between the two groups (P>0.05). After treatment, the MoCA cognitive function score and ADL score increased, but Hcy level decreased in the two groups, and the observation group had better changes than the control group (P<0.05). The incidence of adverse reactions in the control group during treatment was 13.33 %, the incidence of adverse reactions in the observation group was 16.00 %, and there was no statistically significant difference between the two groups (P>0.05). The total effective rate of the study group was significantly higher than that of the control group (93.33% vs. 74.00%, P<0.05). Conclusion: Hyperbaric oxygen combined with folic acid is effective in the treatment of elderly patients with cerebrovascular disease. It can significantly improve patients' cognitive function, Hcy level, and their ability of daily living, with high safety. It was worthy of clinical application. |
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