| 马世军,范晓英,郑仲磊,张万平,杜克信.高血压颅内肿瘤患者预防性吸入七氟醚术中脑血流及颅内压变化分析[J].现代生物医学进展英文版,2021,(8):1576-1579. |
| 高血压颅内肿瘤患者预防性吸入七氟醚术中脑血流及颅内压变化分析 |
| Analysis of Changes in Cerebral Blood Flow and Intracranial Pressure during Prophylactic Inhalation of Sevoflurane in Patients with Hypertension |
| Received:August 26, 2020 Revised:September 21, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.08.039 |
| 中文关键词: 高血压颅内肿瘤 七氟醚 脑血流 颅内压 |
| 英文关键词: Hypertensive intracranial tumor Sevoflurane Cerebral blood flow Intracranial pressure |
| 基金项目:陕西省社会发展科技攻关项目（2016SF-166） |
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| 中文摘要: |
| 摘要 目的：分析高血压颅内肿瘤患者预防性吸入七氟醚术中脑血流及颅内压变化情况。方法：选取2018年8月至2019年8月我院收治的80例高血压颅内肿瘤患者作为研究对象，随机将其分为两组，对照组40例，给予丙泊酚维持麻醉；研究组40例，给予七氟醚维持麻醉，观察两组患者的脑血流及颅内压变化情况。结果：1）两组患者大脑前动脉（anteriorcerebral artery，ACA）、大脑中动脉（middle cerebral artery，MCA）、大脑后动脉（posterior cerebral artery，PCA）血流动力学指标比较，麻醉前（T0）阻力指数（resistance Index，RI）和时间平均流速（the average velocity，Vm）差异无统计学意义(P>0.05)；诱导麻醉（T1）、维持麻醉（T2）、手术结束（T3）时间点RI和Vm比较，研究组均明显优于对照组(P<0.05)；2）两组患者麻醉前颅内压(intracranial pressure，ICP)比较差异无统计学意义(P>0.05)；T1、T2、T3时间点，两组患者ICP进行比较，研究组明显低于对照组(P<0.05)。结论：预防性吸入七氟醚对于高血压颅内肿瘤患者术中能够维持脑血流稳定，同时降低患者的颅内压，使患者深度麻醉，避免术中一些风险事件的发生，具有很好的临床意义，值得推广和应用。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the changes of cerebral blood flow and intracranial pressure during prophylactic inhalation of sevoflurane in patients with hypertensive intracranial tumors. Methods: Eighty patients with hypertensive intracranial tumors admitted to our hospital from August 2018 to August 2019 were selected as the research object, and they were randomly divided into two groups, a control group of 40 patients, and propofol to maintain anesthesia; research group 40 For example, sevoflurane was given to maintain anesthesia, and the changes of cerebral blood flow and intracranial pressure in the two groups were observed. Results: Comparison of hemodynamic indexes of ACA, MCA, PCA, RI and Vm before anesthesia in the two groups of patients. The difference was not statistically significant(P>0.05). The comparison of RI and Vm at T1, T2, and T3, the study group was significantly better than the control group (P<0.05). There was no significant difference in ICP between the two groups of patients before anesthesia(P>0.05). T1, T2, T3 time points, the ICP of the two groups was compared, the research group was significantly lower In the control group(P<0.05). Conclusion: Prophylactic inhalation of sevoflurane can maintain stable cerebral blood flow in patients with hypertensive intracranial tumors, and at the same time reduce the intracranial pressure of the patients, make the patients deep anesthesia, avoid some risk events during the operation, and have a good clinical Significance, worthy of promotion and application. |
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