| 黄理进,张婵娟,何景培,陈海林,董庆龙.普瑞巴林联合前锯肌平面阻滞对胸腔镜肺癌根治术后患者睡眠质量和炎性因子的影响[J].现代生物医学进展英文版,2021,(8):1474-1478. |
| 普瑞巴林联合前锯肌平面阻滞对胸腔镜肺癌根治术后患者睡眠质量和炎性因子的影响 |
| Effects of Pregabalin Combined with Serratus Anterior Plane Block on Sleep Quality and Inflammatory Factors in Patients after Thoracoscopic Radical Resection of Lung Cancer |
| Received:November 24, 2020 Revised:December 18, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.08.016 |
| 中文关键词: 普瑞巴林 前锯肌平面阻滞 胸腔镜肺癌根治术 睡眠质量 炎性因子 |
| 英文关键词: Pregabalin Serratus anterior plane block Thoracoscopic radical resection of lung cancer Sleep quality Inflammatory factors |
| 基金项目:广东省2020年度卫生健康适宜技术推广项目（202006182030549717） |
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| 中文摘要: |
| 摘要 目的：探讨普瑞巴林联合前锯肌平面阻滞(SAPB)对胸腔镜肺癌根治术后患者睡眠质量和血清炎性因子的影响。方法：病例收集时间为2019年3月到2020年7月，筛选符合要求的胸腔镜肺癌根治术后患者60例，采用随机数字表法分为对照组（n=30）和研究组（n=30）。两组患者均给予SAPB，术后均采用静脉自控镇痛，对照组口服安慰剂，研究组于术前2 h口服普瑞巴林150 mg，术后第二天开始口服普瑞巴林75 mg。对比两组镇静、镇痛效果，睡眠质量、血清炎性因子、焦虑情况、生命体征指标及不良反应。结果：研究组术后12 h、24 h、48 h视觉疼痛模拟评分法（VAS）低于对照组，Ramsay评分高于对照组（P<0.05）。研究组术后48h状态-特质焦虑量表(STAI)、匹兹堡睡眠质量指数量表(PSQI)评分低于对照组（P<0.05）。研究组术后24 h、术后48 h白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）低于对照组（P<0.05）。研究组术后4 h、术后24 h、术后48 h心率（HR）低于对照组，收缩压（SBP）、舒张压（DBP）高于对照组（P<0.05）。两组不良反应发生率对比无统计学差异（P>0.05）。结论：普瑞巴林联合SAPB应用于胸腔镜肺癌根治术后患者，可维持患者生命体征平稳，可获得良好的镇痛、镇静效果，改善患者睡眠质量，减轻其焦虑情绪，同时还可降低血清炎性因子水平，安全性好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of pregabalin combined with serratus anterior plane block (SAPB) on sleep quality and serum inflammatory factors in patients after thoracoscopic radical resection of lung cancer. Methods: Cases were collected from March 2019 to July 2020, 60 patients who met the requirements after thoracoscopic radical resection of lung cancer were selected, and randomly divided into control group（n=30）and study group（n=30）. Patients in both groups were given SAPB, postoperative intravenous controlled analgesia was used, and placebo was taken orally in the control group. The study group took pregabalin 150 mg orally at 2 h before operation, and pregabalin 75 mg orally from the second day after operation. The sedative and analgesic effects, sleep quality, serum inflammatory factors, anxiety, vital signs and adverse reactions were compared between the two groups. Results: The visual pain analogue scale (VAS) of the study group at 12 h, 24 h and 48 h after operation were lower than those of the control group, and the Ramsay score was higher than that of the control group (P<0.05). Te scores of State Trait Anxiety Scale (STAI) and Pittsburgh sleep quality index(PSQI) of the study group at 48h after operation were lower than those of the control group(P<0.05). The levels of interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), C-reactive protein (CRP) of the study group were lower than those of the control group 24 h and 48h after operation(P<0.05). The heart rate(HR) of the study group was lower than that of the control group at 4 h, 24 h and 48 h after operation, and the systolic blood pressure(SBP) and diastolic blood pressure (DBP) were higher than those of the control group (P< 0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Pregabalin combined with SAPB can be applied to patients after thoracoscopic radical resection of lung cancer, which can maintain stable vital signs, obtain good analgesic and sedative effects, improve the sleep quality of patients, reduce anxiety, and reduce the level of serum inflammatory factors, and showing good safety. |
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