| 吴秀继,王华茹,关 虹,温义华,王永卿.妊娠期贫血患者血常规、网织红细胞多参数及贫血类型与孕期的关系研究[J].现代生物医学进展英文版,2021,(7):1391-1395. |
| 妊娠期贫血患者血常规、网织红细胞多参数及贫血类型与孕期的关系研究 |
| Study on the Relationship between Blood Routine, Multiple Parameters of Reticulocytes, Anemia Types and Pregnancy in Patients with Anemia during Pregnancy |
| Received:October 07, 2020 Revised:October 31, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.07.042 |
| 中文关键词: 妊娠期贫血 网织红细胞多参数 血常规 贫血类型 孕期 |
| 英文关键词: Anemia during pregnancy Multiple parameters of reticulocytes Blood routine Anemia types Pregnancy |
| 基金项目:海南省卫生计生行业科研项目（18A200020） |
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| 中文摘要: |
| 摘要 目的：探讨妊娠期贫血患者血常规、网织红细胞多参数、贫血类型与孕期的关系。方法：纳入我院2018年9月～2019年9月收治的妊娠期贫血患者110例，按孕期分成孕早期组（n=32）、孕中期组（n=35）、孕晚期组（n=43），均检测血常规[血红蛋白（Hb）、红细胞平均体积（MCV）、外周血红细胞计数（RBC）、红细胞比容（HCT）、平均红细胞血红蛋白浓度（MCHC）]、网织红细胞参数[网织红细胞绝对值（RET#）、低荧光强度网织红细胞百分率（LFR%）、网织红细胞百分率（RET%）、中荧光强度网织红细胞百分率（MFR%）、高荧光强度网织红细胞百分率（HFR%）]。分析各参数与孕期相关性，比较三组贫血类型。结果：孕早期组Hb、RBC、HCT、MCHC、LFR%较孕中期组、孕晚期组增高，其中孕中期组较孕晚期组增高（P＜0.05），孕早期组RET#、RET%、MFR%、HFR%较孕中期组、孕晚期组降低，且孕中期组较孕晚期组降低（P＜0.05），孕晚期组MCV高于孕早期组、孕中期组（P＜0.05）。Pearson线性相关分析提示，Hb、RBC、HCT、MCHC、LFR%与孕期呈负相关（P＜0.05），RET#、RET%、MFR%、HFR%与孕期呈正相关（P＜0.05）。孕早期组、孕中期组小细胞贫血占比高于孕晚期组，大细胞贫血占比低于孕晚期组（P＜0.05）。结论：妊娠期贫血患者随着孕周的延长，Hb、RBC、HCT、MCHC、LFR%下降，而RET#、RET%、MFR%、HFR%增高，孕晚期以大细胞贫血为主，早、中期以小细胞贫血为主，加强上述指标的检测对妊娠期贫血患者诊断和治疗具有一定的临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between blood routine, multiple parameters of reticulocytes, anemia types and pregnancy in patients with anemia during pregnancy. Methods: Include 110 patients with anemia during pregnancy admitted to our hospital from September 2018 to September 2019, and were divided into first trimester group (n=32), second trimester group (n=35) and third trimester group (n=43) according to pregnancy. All subjects were tested for blood routine [hemoglobin (Hb), mean corpuscular volume (MCV), red blood cell (RBC), hematocrit (HCT), mean corpuscular hemoglobin concentration (MCHC)], net red blood cell parameters [reticulocyte absolute value (RET#), low fluorescence intensity reticulocyte percentage (LFR%), reticulocyte ratio (RET%), moderate fluorescent intensity reticulocyte percentage (MFR%), height fluorescent intensity reticulocyte percentage (HFR%)]. The correlation between the parameters and pregnancy was analyzed, and the anemia types of the three groups were compared. Results: Hb, RBC, HCT, MCHC and LFR% in the first trimester group were higher than those in the second trimester group and third trimester group, and the second trimester group was higher than the third trimester group (P＜0.05). RET#, RET%, MFR% and HFR% in the first trimester group were lower than those in the second trimester group and third trimester group, and the second trimester group was lower than the third trimester group (P＜0.05). MCV in third trimester group was higher than that in first trimester group and second trimester group (P＜0.05). Pearson linear analysis showed that Hb, RBC, HCT, MCHC, LFR% were negatively correlated with pregnancy (P＜0.05), RET#, RET%, MFR%, HFR% were positively correlated with pregnancy (P＜0.05). The proportion of small cell anemia in the first trimester group and second trimester group was higher than that in the third trimester group, and the proportion of large cell anemia was lower in the third trimester group (P < 0.05). Conclusion: Hb, RBC, HCT, MCHC and LFR% are decreased with the prolongation of gestational weeks, while RET#, RET%, MFR% and HFR% are increased. Large cell anemia is predominant in the third trimester, and small cell anemia is predominant in the first and second trimester. Strengthening the detection of the above indicators has certain clinical significance for the diagnosis and treatment of gestational anemia. |
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