| 王淑慧,高雪婷,周银月,高 欣,肖 琳.儿童运动发育迟缓与血碱性磷酸酶、血25-羟维生素D3表达水平的相关性[J].现代生物医学进展英文版,2021,(7):1356-1359. |
| 儿童运动发育迟缓与血碱性磷酸酶、血25-羟维生素D3表达水平的相关性 |
| Correlation between Children's Motor Development Delay and Expression of Blood Alkaline Phosphatase and Blood 25-hydroxyvitamin D3 |
| Received:September 05, 2020 Revised:September 28, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.07.034 |
| 中文关键词: 儿童 运动发育迟缓 碱性磷酸酶 25-羟维生素D3 相关性 |
| 英文关键词: Children Motor developmental delay Alkaline phosphatase 25-hydroxyvitamin D3 Correlation |
| 基金项目:陕西省卫生健康委基金项目(2018E014) |
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| 中文摘要: |
| 摘要 目的：探讨儿童运动发育迟缓与血碱性磷酸酶(Alkaline phosphatase，ALP)、血25-羟维生素D3[25(OH)D3]表达水平的相关性。方法：2016年10月到2018年6月选择在本院儿保科门诊就诊500例(6~12月龄)的儿童作为研究对象，诊断儿童发育迟缓的发生率，检测发育迟缓患儿血清ALP与25(OH)D3水平，Gesell测评评定小儿的运动发育状况，所有患儿每天均给予了维生素D3 400 IU，对于发育迟缓患儿每天给予维生素D 800 IU~1200 IU补充，治疗3个月，再做Gesell测评评估其运动发育水平，对比治疗后运动发育情况，并分析影响儿童运动发育的相关因素。结果：在500例小儿中，判断为运动发育迟缓120例(迟缓组)，占比24.0 %。两组小儿的性别、胎龄、分娩方式、出生体重、头围、身长等对比差异无统计学意义(P>0.05)。迟缓组的血清ALP水平高于非迟缓组(P<0.05)，25(OH)D3水平低于非迟缓组(P<0.05)。迟缓组的大动作、精细运动、适应性行为、语言、个人社交评分都低于非迟缓组(P<0.05)，迟缓组治疗后，大动作、精细运动、适应性行为、语言、个人社交评分均显著升高(P<0.05)。在120例发育迟缓中，Pearson分析显示ALP、25(OH)D3与小儿运动迟缓发育具有相关性(P<0.05)；二分类多因素条件Logistic分析结果显示ALP、25(OH)D3都影响儿童运动发育迟缓的主要因素(P<0.05)。结论：儿童运动发育迟缓与血清ALP、25(OH)D3水平存在相关性，两者的联合检测可为儿童发育迟缓的早期诊断提供实验依据，经过维生素D治疗后，能显著的改善其患儿的运动发育，有很好的应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation between children's motor developmental delay and the expression of blood alkaline phosphatase (ALP) and blood 25-hydroxyvitamin D3[25(OH)D3]. Methods: A total of 500 children from 6 - 12 months of age,who went to the pediatric health care department of Northwest Women and Children's Hospital for seeking medical advice from October 2016 to June 2018, were chosen as research subjects. All the children were given 400 IU of vitamin D3 every day, and 800 IU~1200 IU of vitamin D was given to children with developmental delay every day for 3 months. The Gesell test was performed to evaluate their motor development level, and the motor development after treatment was compared. The related factors that affect developmental delay were analyzed. Results: Among 500 children, 120 cases were judged to be motor development retardation (delayed group), accounting for 24.0%. There were no significant differences in gender, gestational age, delivery method, birth weight, head circumference, and length between the two groups of children (P>0.05). The serum ALP level of the retarded group was higher than that of the non-retardant group (P<0.05), and the 25(OH)D3 level was lower than that of the non-retarded group (P<0.05). After treatment, the major motor, fine motor, adaptive behavior, language, and personal social scores of the retarded group Both were significantly increased (P<0.05). Among 120 cases of developmental delay, Pearson analysis showed that ALP and 25(OH)D3 were correlated with children's motor retardation development (P<0.05); the results of two-category multivariate conditional Logistic analysis showed that both ALP and 25(OH)D3 were the main factors of affecting children's motor retardation development (P<0.05). Conclusion: There is correlation between children's motor development delay and serum ALP and 25(OH)D3 levels. The combined detection of the two can provide experimental evidence for the early diagnosis of children's developmental delay. After vitamin D treatment, the motor development of children can be significantly improved, with better application value. |
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