| 汪 伟,王 彬,张立春,高 峰,吴 蔚.加味麻杏石甘汤联合噻托溴铵对慢性阻塞性肺疾病急性加重期患者肺功能、血气指标及炎症因子的影响[J].现代生物医学进展英文版,2021,(6):1046-1050. |
| 加味麻杏石甘汤联合噻托溴铵对慢性阻塞性肺疾病急性加重期患者肺功能、血气指标及炎症因子的影响 |
| Effect of Modified Maxingshigan Decoction Combined with Tiotropium Bromide on Pulmonary Function, Blood Gas Index and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
| Received:July 29, 2020 Revised:August 24, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.06.010 |
| 中文关键词: 加味麻杏石甘汤 噻托溴铵 肺功能 血气指标 慢性阻塞性肺疾病急性加重期 炎症因子 |
| 英文关键词: Modified Maxingshigan Decoction Tiotropium bromide Lung function Blood gas index Acute exacerbation of chronic obstructive pulmonary disease Inflammatory factors |
| 基金项目:北京市科委计划项目（z181100001718114）；中国中医科学院基本科研业务费自主选题项目（ZZ11-081） |
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| 中文摘要: |
| 摘要 目的：探讨加味麻杏石甘汤联合噻托溴铵对慢性阻塞性肺疾病急性加重期（AECOPD）患者肺功能、血气指标及炎症因子的影响。方法：选取2018年2月-2019年11月我院收治的97例AECOPD患者，按随机数字表法将其分为对照组（n=48，噻托溴铵治疗）、研究组（n=49，加味麻杏石甘汤联合噻托溴铵治疗），比较两组患者疗效、中医证候积分、肺功能、血气指标、炎症因子及不良反应。结果：治疗14 d后研究组临床总有效率较对照组高（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。两组治疗14 d后中医证候积分均下降，且研究组低于对照组（P<0.05）。两组治疗14 d后第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC均较治疗前升高，且研究组高于对照组（P<0.05）。两组治疗14 d后动脉血氧分压（PO2）升高，且研究组高于对照组（P<0.05），二氧化碳分压（PCO2）下降，且研究组低于对照组（P<0.05）。两组治疗14 d后血清白细胞介素-8（IL-8）、C反应蛋白（CRP）水平均下降，且研究组低于对照组（P<0.05）。结论：加味麻杏石甘汤联合噻托溴铵治疗AECOPD患者，疗效显著，可有效改善患者临床症状、肺功能、血气指标及炎症因子，且安全可靠。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of modified Maxingshigan decoction combined with tiotropium bromide on pulmonary function, blood gas index and inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 97 patients with AECOPD in our hospital from February 2018 to November 2019 were selected, they were divided into control group (n=48, tiotropium bromide treatment) and study group (n=49, modified Maxingshigan decoction and tiotropium bromide treatment) by random number table method. The therapeutic effect, TCM syndrome score, lung function, blood gas index, inflammatory factors and adverse reactions were compared between the two groups. Results: 14 d after treatment, the total clinical effective rate of the study group was higher than that of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). The scores of TCM syndromes in the two groups 14 d after treatment decreased, and the study group was lower than the control group(P<0.05). The forced expiratory volume at 1 second (FEV1), forced vital capacity (FVC) and FEV1/ FVC at 14 d after treatment in the two groups were higher than those before treatment, and the study group was higher than control group (P<0.05). 14 d after treatment, the arterial oxygen partial pressure (PO2) of the two groups increased, and the study group was higher than that of the control group (P<0.05), and the partial pressure of carbon dioxide (PCO2) of the study group was lower than that of the control group (P<0.05). The levels of interleukin-8 (IL-8), c-reactive protein (CRP) in the two groups decreased at 14 d after treatment, and the level in the study group was lower than that in the control group (P<0.05). Conclusion: Modified Maxingshigan decoction combined with tiotropium bromide is effective in the treatment of AECOPD, which can effectively improve the clinical symptoms, lung function, blood gas index and inflammatory factors, and is safe and reliable. |
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