| 孙 娜,高树苓,安 朗,王 洋,鞠 策.卵巢早衰患者血清抑制素B、抗苗勒管激素及性激素水平与子宫动脉血流参数的相关性研究[J].现代生物医学进展英文版,2021,(5):992-995. |
| 卵巢早衰患者血清抑制素B、抗苗勒管激素及性激素水平与子宫动脉血流参数的相关性研究 |
| Correlation Study between Serum Inhibin B and Anti-Mullerian Hormone and Sex Hormones Level and Uterine Artery Blood Flow Parameters in Patients with Premature Ovarian Failure |
| Received:September 07, 2020 Revised:September 30, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.05.041 |
| 中文关键词: 卵巢早衰 抑制素B 抗苗勒管激素 性激素 子宫动脉血流 |
| 英文关键词: Premature ovarian failure Inhibin B Anti-Mullerian Hormone Sex hormones Uterine arteries blood flow |
| 基金项目:国家自然科学基金项目（81202049） |
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| 中文摘要: |
| 摘要 目的：探讨卵巢早衰（POF）患者血清抑制素B（INHB）、抗苗勒管激素（AMH）及性激素水平与子宫动脉血流参数的相关性。方法：选择2018年5月至2020年5月期间我院收治的126例POF患者（POF组）和同期于我院进行体检的85例健康女性志愿者（对照组）。检测所有研究对象血清INHB、AMH以及促黄体生成素（LH）、促卵泡激素（FSH）、雌二醇（E2）水平，经阴道多普勒超声检测子宫动脉血流参数[收缩期峰值流速（PSV）、舒张末期流速（EDV），血流阻力指数（RI）、搏动指数（PI）]。Pearson相关性分析POF患者血清INHB、AMH、LH、FSH、E2水平与PSV、EDV、RI、PI的相关性。结果：POF组血清INHB、AMH、E2水平、PSV、EDV低于对照组（P＜0.05），LH 、FSH水平、RI、PI高于对照组（P＜0.05）。Pearson相关性分析结果显示POF患者血清INHB、AMH、E2水平与PSV、EDV呈正相关（P＜0.05），与RI、PI呈负相关（P＜0.05），LH 、FSH与PSV、EDV呈负相关（P＜0.05），与RI、PI呈正相关（P＜0.05）。结论：POF患者血清INHB、AMH、E2水平降低，LH 、FSH水平升高，血清INHB、AMH和性激素与子宫动脉血流受限有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum inhibin B (INHB) and Anti-Mullerian Hormone (AMH) and sex hormones level and uterine artery blood flow parameters in patients with premature ovarian failure (POF). Methods: From May 2018 to May 2020, 126 patients with POF (POF group) who were admitted to our hospital and 85 healthy female volunteers (control group) who underwent physical examination in our hospital during the same period were selected. The serum INHB, AMH, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol (E2) levels were measured in all subjects. Uterine artery blood flow parameters [peak systolic velocity (PSV), end-diastolic velocity (EDV), blood flow resistance index (RI), pulse index (PI)] were measured by transvaginal Doppler Ultrasonography. Pearson correlation analyzed was used to analyze the correlation between serum INHB, AMH, LH, FSH, E2 levels and PSV, EDV, RI, PI in patients with POF. Results: Serum INHB, AMH, E2 levels, PSV, EDV in POF group were lower than those in control group (P<0.05), LH, FSH levels, RI, PI were higher than those in control group (P<0.05). Pearson correlation analysis showed that serum INHB, AMH and E2 levels of patients with POF were positively correlated with PSV and EDV (P＜0.05), and negatively correlated with RI and PI (P＜0.05), LH and FSH were negatively correlated with PSV and EDV (P＜0.05), and positively correlated with RI and PI (P＜0.05). Conclusion: In patients with POF, serum INHB, AMH and E2 levels are decreased, LH and FSH levels are increased, serum INHB, AMH and sex hormones are associated with uterine artery blood flow limitation. |
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