| 邓万生,孙 振,王 伟,郑福爽,曹 辉.非小细胞肺癌组织MAGE-A3、HIF-1α、MTA1表达与临床病理参数及复发转移的关系研究[J].现代生物医学进展英文版,2021,(5):945-949. |
| 非小细胞肺癌组织MAGE-A3、HIF-1α、MTA1表达与临床病理参数及复发转移的关系研究 |
| Study on the Relationship between the Expression of MAGE-A3, HIF-1α, MTA1, Clinicopathological Parameters, Recurrence and Metastasis in Non Small Cell Lung Cancer |
| Received:July 26, 2020 Revised:August 22, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.05.031 |
| 中文关键词: 非小细胞肺癌；黑色素瘤相关抗原-A3；缺氧诱导因子-1?琢；转移相关蛋白1；临床病理参数；复发 转移 |
| 英文关键词: Non-small cell lung cancer Melanoma associated antigen-A3 Hypoxia inducible factor-1 ?琢 Metastasis associated protein-1 Clinicopathological parameters Recurrence Metastasis |
| 基金项目:国家自然科学基金项目（30979171）；辽宁省自然科学基金计划项目(20180530020) |
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| 中文摘要: |
| 摘要 目的：探讨非小细胞肺癌组织黑色素瘤相关抗原-A3（MAGE-A3）、缺氧诱导因子-1α（HIF-1α）、转移相关蛋白1（MTA1）表达与临床病理参数及复发转移的关系。方法：选择2015年2月至2018年1月我院诊治的130例非小细胞肺癌患者进行临床研究，采用免疫组织化学染色法检测其非小细胞癌组织及癌旁组织中MAGE-A3、HIF-1α、MTA1的表达，分析MAGE-A3、HIF-1α、MTA1的表达与各项临床病理参数的关系。对比不同MAGE-A3、HIF-1α、MTA1表达情况患者的转移率及复发率。结果：130例非小细胞肺癌组织中MAGE-A3、HIF-1α、MTA1阳性率分别为70.77%、74.62%、79.23%，明显高于癌旁组织的25.38%、22.31%、17.69%（P<0.05）。非小细胞肺癌组织中MAGE-A3、HIF-1α、MTA1表达与淋巴结转移和TNM分期相关（P<0.05）。MAGE-A3、HIF-1α、MTA1阳性患者转移/复发率明显高于MAGE-A3、HIF-1α、MTA1阴性患者（P<0.05）。结论： MAGE-A3、HIF-1α、MTA1在非小细胞肺癌中阳性表达率升高，并且均与非小细胞肺癌淋巴结转移、TNM分期和转移复发相关，在非小细胞肺癌的诊断和预后评估中具有一定临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of melanoma associated antigen-A3 (MAGE-A3), hypoxia inducible factor-1 α (HIF-1α), metastasis associated protein-1 (MTA1) and clinicopathological parameters, recurrence and metastasis of non small cell lung cancer（NSCLC）. Methods: 130 cases of NSCLC who were diagnosed and treated in our hospital from february 2015 to January 2018 were selected for clinical study. The expression of MAGE-A3, HIF-1α and MTA1 in NSCLC and its adjacent tissues were detected by immunohistochemistry. The relationship between the expression of MAGE-A3, HIF-1α and MTA1 and various clinicopathological parameters was analyzed. The metastasis rate and recurrence rate of patients with different expression of MAGE-A3, HIF-1 α and MTA1 were compared. Results: The positive rates of MAGE-A3, HIF-1α and MTA1 in 130 NSCLC tissues were 70.77%, 74.62% and 79.23%, respectively, which were significantly higher than those in adjacent tissues (25.38%, 22.31%, 17.69%) (P<0.05). The expression of MAGE-A3, HIF-1 α and MTA1 in NSCLC was correlated with lymph node metastasis and TNM stage (P<0.05). The metastasis rate and recurrence rate of MAGE-A3, HIF-1α, MTA1 positive patients were significantly higher than those of MAGE-A3, HIF-1α, MTA1 negative patients (P<0.05). Conclusion: The positive expression rate of MAGE-A3, HIF-1α and MTA1 in NSCLC is increased, and they are all related to lymph node metastasis, TNM stage and metastasis recurrence of NSCLC. |
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