| 冯惠燕,陈东雄,黄锦珠,田梦源,范冠杰.加味消痞汤对脾虚痰瘀型高脂血症患者血脂水平及中医证候症状的影响[J].现代生物医学进展英文版,2021,(5):876-879. |
| 加味消痞汤对脾虚痰瘀型高脂血症患者血脂水平及中医证候症状的影响 |
| Effect of Jiawei Xiaopi Decoction on Blood Lipid Level and TCM Syndrome Symptoms in Patients with Hyperlipidemia of Spleen Deficiency and Phlegm Stasis Type |
| Received:June 23, 2020 Revised:July 18, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.05.015 |
| 中文关键词: 加味消痞汤 脾虚痰瘀 高脂血症 血脂 中医证候 |
| 英文关键词: Jiawei Xiaopi Decoction Spleen deficiency and phlegm stasis Hyperlipidemia Blood lipid TCM Syndrome |
| 基金项目:"十二五"国家科技支撑计划项目（2015BAI04B00） |
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| 中文摘要: |
| 摘要 目的：探讨加味消痞汤治疗脾虚痰瘀型高脂血症（HL）的临床疗效，并探讨其对血脂水平及中医证候症状的影响。方法：选择2018年8月~2019年12月我院收治的脾虚痰瘀型HL患者96例，按照随机数字表法将其分为观察组50例和对照组46例，观察组采用加味消痞汤治疗，对照组采用血脂康胶囊治疗。比较两组患者临床疗效、治疗前后血脂变化、中医证候积分变化及药物治疗期间不良反应发生情况。结果：观察组患者治疗总有效率94.00%显著高于对照组78.26%，差异具有统计学意义（P<0.05）。治疗后两组患者总胆固醇（TC）、甘油三脂（TG）以及低密度脂蛋白胆固醇（LDL-C）水平较治疗前明显下降（P<0.05），而高密度脂蛋白胆固醇（HDL-C）水平显著升高（P<0.05），且治疗后观察组患者TC、TG以及LDL-C水平低于对照组，HDL-C水平高于对照组（P<0.05）。两组患者治疗后中医证候总积分均明显低于治疗前，且观察组低于对照组（P<0.05）。两组患者治疗前后肝肾功能、血尿常规均无明显异常，且治疗期间两组患者均未发生药物相关不良反应。结论：加味消痞汤治疗脾虚痰瘀型HL患者，临床疗效确切，能够有效降低患者血脂水平，且患者临床症状改善明显，用药安全，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of Jiawei Xiaopi Decoction on hyperlipidemia(HL) of spleen deficiency and phlegm stasis type, and to explore its effect on blood lipid level and TCM syndrome symptoms. Methods: From August 2018 to December 2019, 96 HL patients of spleen deficiency and phlegm stasis type were selected and divided into observation group (50 cases) and control group (46 cases) according to the method of random number table. The observation group was treated with Jiawei Xiaopi Decoction and the control group was treated with Xuezhikang Capsule. The clinical effect, changes of blood lipid before and after treatment, changes of TCM syndrome score and adverse reactions during the treatment were compared between the two groups. Results: The total effective rate of 94.00% in the observation group was significantly higher than 78.26% in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of TC, TG and LDL-C in the two groups were significantly lower than those before treatment (P<0.05), while the levels of HDL-C were significantly higher (P<0.05), and the levels of TC, TG and LDL-C in the observation group were lower than those in the control group, the levels of HDL-C were higher than those in the control group (P<0.05). The total score of TCM syndrome in the two groups after treatment was significantly lower than that before treatment (P<0.05), and the observation group was lower than the control group (P<0.05). there were no significant abnormalities in liver and kidney function, blood and urine routine, and no drug-related adverse reactions occurred in the two groups during the treatment. Conclusion: Jiawei Xiaopi decoction can effectively reduce the blood lipid level of patients with HL of spleen deficiency and phlegm stasis type, and the clinical symptoms of patients are improved significantly, and the drug is safe, which is worthy of clinical application. |
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