| 李渝阳,陈红艳,赵 晋,李 巧,张 骁.自杀未遂老年抑郁症患者血清5-羟色胺水平、总胆固醇、C反应蛋白及白介素-6检测的临床意义[J].现代生物医学进展英文版,2021,(4):738-741. |
| 自杀未遂老年抑郁症患者血清5-羟色胺水平、总胆固醇、C反应蛋白及白介素-6检测的临床意义 |
| Clinical Significance of Detection of Serum Serotonin Level, Total Cholesterol, C-reactive Protein and Interleukin-6 in Elderly Patients with Suicide Attempted Depression |
| Received:July 10, 2020 Revised:August 05, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.04.029 |
| 中文关键词: 老年 抑郁症 自杀未遂 5-羟色胺 总胆固醇 C反应蛋白 白介素-6 |
| 英文关键词: Elderly Depression Suicide attempted 5-hydroxytryptamine Total cholesterol C-reactive protein Interleukin-6 |
| 基金项目:重庆市精神卫生中心院级科研项目（2019-yjkt-17） |
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| 中文摘要: |
| 摘要 目的：探讨自杀未遂老年抑郁症患者血清5-羟色胺（5-HT）水平、总胆固醇（TC）、C反应蛋白（CRP）及白介素-6（IL-6）检测的临床意义。方法：选取2015年5月至2018年5月我院收治的首次住院的老年抑郁症患者155例，依据入院前2周内是否曾有过自杀行为将其分为自杀未遂组（n=75）和无自杀行为组（n=80）。比较两组患者的临床指标及血清5-HT、TC、CRP及IL-6水平；分析不同病情严重程度自杀未遂老年抑郁症患者血清5-HT、TC、CRP及IL-6水平；采用Pearson相关分析血清5-HT、TC、CRP及IL-6水平与汉密尔顿抑郁量表（HAMD）评分的相关性。结果：自杀未遂组HAMD评分高于无自杀行为组（P<0.05）。自杀未遂组血清5-HT及TC水平均低于无自杀行为组（P<0.05），自杀未遂组血清CRP及IL-6水平均高于无自杀行为组（P<0.05）。与轻度组比较，中度组、重度组患者血清5-HT及TC水平均明显降低，且重度组低于中度组 (P<0.05)；与轻度组比较，中度组和重度组患者血清CRP及IL-6水平均明显升高，且重度组高于中度组 (P<0.05)。5-HT、TC与HAMD评分呈负相关（P<0.05）；CRP、IL-6与HAMD评分呈正相关（P<0.05）。结论：自杀未遂老年抑郁症患者血清5-HT、TC水平降低，CRP、IL-6水平升高，检测血清5-HT、TC、CRP及IL-6有助于评价其病情严重程度及出现自杀行为的风险。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical significance of detection of serum 5-hydroxytryptamine (5-HT) level, total cholesterol (TC), C-reactive protein (CRP) and interleukin-6 (IL-6) in elderly patients with suicide attempted depression. Methods: 155 elderly patients with depression who were hospitalized for the first time in our hospital from May 2015 to May 2018 were selected. According to whether they had committed suicidal behavior within 2 weeks before admission, they were divided into suicide attempt group (n=75) and non-suicide behavior group (n=80). The clinical indexes and serum 5-HT, TC, CRP and IL-6 levels were compared between the two groups. The severity of the disease and the levels of 5-HT, TC, CRP and IL-6 in elderly patients with depression were analyzed. The relationship between serum 5-HT, TC, CRP, and IL-6 levels and the Hamilton Depression Rating Scale (HAMD) score was analyzed using Pearson correlation analysis. Results: The HAMD score of the suicide attempt group was higher than that of the non-suicide behavior group (P<0.05). Serum 5-HT and TC levels in suicide attempt group were lower than those in non-suicide behavior group (P<0.05). Serum CRP and IL-6 levels in suicide attempt group were higher than those in non-suicide behavior group (P<0.05). Compared with the mild group, the serum 5-HT and TC levels in the moderate group and the severe group were significantly lower, and the severe group was lower than the moderate group (P<0.05). Compared with the mild group, the serum CRP and IL-6 levels were significantly higher in the moderate group and severe group. High, and the severe group was higher than the moderate group (P<0.05). 5-HT, TC and HAMD scores were negatively correlated (P<0.05); CRP, IL-6 were positively correlated with HAMD score (P<0.05). Conclusion: Serum 5-HT and TC levels are decreased, and CRP and IL-6 levels are increased in elderly patients with depression after suicide attempt. Detection of serum 5-HT, TC, CRP and IL-6 are helpful in assessing the severity of their disease and the risk of suicidal behaviors. |
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