| 周 敏,李 涛,苏林娜,袁旭龙,任卫华.不同声功率聚焦超声治疗不同时期胰腺癌疗效分析[J].现代生物医学进展英文版,2021,(4):668-672. |
| 不同声功率聚焦超声治疗不同时期胰腺癌疗效分析 |
| Analysis of Therapeutic Effect of Different Sound Power Focused Ultrasound on Pancreatic Cancer in Different Periods |
| Received:July 06, 2020 Revised:July 28, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.04.014 |
| 中文关键词: 超声消融 胰腺癌 疗效 声功率 |
| 英文关键词: Ultrasound ablation Pancreatic cancer Efficacy Sound power |
| 基金项目:陕西省自然科学基础研究计划项目(2018JQ7021) |
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| 中文摘要: |
| 摘要 目的：对不同声功率聚焦超声治疗不同时期胰腺癌疗效进行分析。方法：以胰腺癌患者为研究对象，分为低功率组和高功率组，其中低功率组治疗功率为100～249 W，高功率组治疗功率为250～350 W，以疼痛缓解效果、肿瘤坏死体积和体积消融率、血管内皮生长因子(vascular endothelial growth facto，VEGF)和肝细胞生长因子(hepatocyte growth factor，HGF)水平、并发症和生存时间为指标，评价治疗效果。结果：低功率疼痛缓解总有效率为97.5 %，高功率组总有效率为92.5 %，两组比较无显著差异（P＞0.05)；所有患者的胰腺癌肿瘤均呈现不同程度的坏死，且坏死区域体积在1~3个月内逐渐缩小，表现为增强扫描无强化，肿瘤周围存在环形强化带；高功率组III~IV期患者的肿瘤体积消融率显著高于低功率组（P＜0.05）；与治疗前相比，低功率组和高功率组III~IV分期患者的VEGF和HGF水平均显著下降，与低功率组相比，高功率组各时期VEGF和HGF水平降低更显著（P＜0.05）；高功率组和低功率组并发症发生率分别为12.5 %和15.0 %，经比较无统计学差异（P＞0.05）；治疗后低功率组患者中位生存期为6.37±1.13个月，高功率组患者中位生存期为6.72±1.34个月，经比较无显著差异（P＞0.05）。结论：不同声功率聚焦超声消融治疗不同时期胰腺癌均有较好疗效，减轻患者疼痛，延长中位生存期，安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To analysis of the therapeutic effect of different sound power focused ultrasound on pancreatic cancer in different periods. Methods: The patients with pancreatic cancer were divided into low-power group and high-power group. The treatment power of low-power group is 100～249 W, and the treatment power of high-power group is 250~350 W. The therapeutic effect was evaluated using pain relief effect, tumor necrosis volume and volume ablation rate, VEGF and HGF levels, complications and survival time. Results: The total effective rate of low power is 97.5 %, the total effective rate of high power group is 92.5 %, there is no significant difference between the two groups (P>0.05). Pancreatic cancer tumors of all patients showed varying degrees of necrosis, and the volume of the necrotic area gradually reduced within 1 to 3 months, which showed that the enhancement scan had no enhancement, and there was a ring-shaped enhancement zone around the tumor; The tumor volume ablation rate in the stage III-IV patients in the high-power group was significantly higher than the low-power group (P<0.05). Compared with before treatment, the levels of VEGF and HGF in patients in low-power group and high-power group III to IV stage were significantly decreased. Compared with the low-power group, the levels of VEGF and HGF in the high-power group in each period decreased more significantly (P<0.05). The incidence of complications in the high-power group and the low-dose group were 12.5 % and 15.0 %, respectively, and there was no statistical difference (P>0.05) after comparison. After treatment, the median survival time of patients in the low-power group was 6.37±1.13 months, and the median survival time of patients in the high-power group was 6.72±1.34 months. There was no significant difference (P>0.05). Conclusion: Different sound power focused ultrasound ablation has better efficacy in treating pancreatic cancer in different periods, reducing patients' pain, prolonging the median survival time, and having better safety. |
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