| 曾 晖,朱明亮,袁 晖,闫国防,李广华.微创钻孔引流术对高血压脑出血患者近期疗效及颅内感染、血肿再扩大的影响[J].现代生物医学进展英文版,2021,(1):170-173. |
| 微创钻孔引流术对高血压脑出血患者近期疗效及颅内感染、血肿再扩大的影响 |
| Hypertensive Cerebral Hemorrhage：Short-term Effect of Minimally Invasive Drilling and Drainage on Patients and Role of Intracranial Infection and Hematoma Enlargement |
| Received:August 28, 2020 Revised:September 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.01.038 |
| 中文关键词: 微创钻孔引流术 高血压脑出血 近期疗效 颅内感染 |
| 英文关键词: Minimally invasive drilling and drainage Hypertensive cerebral hemorrhage Short-term effects Intracranial infection |
| 基金项目:湖南省自然科学基金项目(2016JJ6084) |
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| 中文摘要: |
| 摘要 目的：研究微创钻孔引流术对高血压脑出血患者近期疗效及颅内感染、血肿再扩大的影响。方法：选取2017年3月至2019年2月的81例高血压脑出血患者。按照随机数表法分为观察组（n=42）和对照组（n=39），对照组采用常规开颅血肿清除术治疗，观察组采用微创钻孔引流术治疗。观察两组治疗疗效情况，血肿量、髓鞘碱性蛋白(MBP)、中枢神经特异蛋白S100水平、NIHSS、GCS评分，不良反应情况。结果：治疗后，观察组总有效率显著高于对照组[92.86％（39/42）vs69.23%（27/39）]（P＜0.05）；血肿量、MBP、S100水平均显著低于对照组[（9.32±2.70）mL vs（15.51±3.01）mL，（3.65±0.52）μg/L vs（4.20±0.71）μg/L，（0.98±0.26）μg/L vs（1.39±0.35）μg/L]（P＜0.05）；NIHSS评分显著低于对照组[（3.90±2.71）分vs（6.34±1.42）分（P＜0.05）；GCS评分显著高于对照组［（14.84±3.52）分vs（10.69±3.98）分］（P＜0.05）；不良反应总发生率显著低于对照组[9.52％（4/42）vs38.46%（15/39）]（P＜0.05）。结论：微创钻孔引流术治疗高血压脑出血患者的近期疗效显著，血肿清除彻底，可有效改善脑神经缺损，减少颅内感染，促进预后恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To study the short-term effect of minimally invasive drilling and drainage on patients with hypertensive cerebral hemorrhage and the role of intracranial infection and hematoma enlargement. Methods: A total of 81 patients with hypertensive cerebral hemorrhage, who received therapy from March 2017 to February 2019 in 922 Hospital of joint logistics support force of Chinese people's Liberation Army, were chosen as research subjects and were randomly divided into observation group (n=42) and control group (n=39). The control group was treated with removal of hematoma by conventional craniotomy, while the observation group was treated with minimally invasive drilling and drainage. Then the therapeutic effect, Hematoma volume, Myelin basic protein (MBP), central nerve specific protein S100 level, NIHSS, GCS score, adverse reactions of the two groups after treatment were compared. Results: After treatment, The total effective rate [92.86％（39/42）] of observation group was significantly higher than that [69.23%（27/39）] of control group（P＜0.05）. Hematoma volume, MBP, S100 levels were significantly lower than those in the control group [（9.32±2.70）mL vs（15.51±3.01）mL,（3.65±0.52）μg/L vs（4.20±0.71）μg/L,（0.98±0.26）μg/L vs（1.39±0.35）μg/L]（P＜0.05）. NIHSS score was significantly lower than that of the control group[（3.90±2.71）scores vs（6.34±1.42）scores]（P＜0.05）. GCS score was significantly higher than that of the control group［（14.84±3.52）scores vs（10.69±3.98）scores］（P＜0.05）. The total incidence of adverse reactions was significantly lower than that of the control group[9.52％（4/42）vs38.46%（15/39）]（P＜0.05）. Conclusion: Minimally invasive drilling and drainage has a significant short-term effect in the treatment of patients with hypertensive intracerebral hemorrhage. It can completely remove the hematoma, which can effectively improve the brain nerve defect, reduce intracranial infection, and promote the recovery of prognosis of the patients. |
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