| 贾晓东,孙飞一,徐 嵩,刘 琳,吴昕倩.急性脑梗死患者颈动脉斑块内新生血管超声造影评价及其与血脂指标和超敏C反应蛋白水平的关系研究[J].现代生物医学进展英文版,2021,(1):129-132. |
| 急性脑梗死患者颈动脉斑块内新生血管超声造影评价及其与血脂指标和超敏C反应蛋白水平的关系研究 |
| Study on the Evaluation of Neovascularization in Carotid Plaque of Patients with Acute Cerebral Infarction by Contrast-enhanced Ultrasound and Its Relationship with Blood Lipid Index and High-sensitivity C-reactive Protein Levels |
| Received:March 28, 2020 Revised:April 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.01.028 |
| 中文关键词: 急性脑梗死 颈动脉斑块 超声造影 脂代谢 炎症反应 病情 预后 |
| 英文关键词: Acute cerebral infarction Carotid plaque Neovascular ultrasound Lipid metabolism Inflammatory response Condition Prognosis |
| 基金项目:辽宁省重点研发计划指导性项目（17112091） |
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| 中文摘要: |
| 摘要 目的：探讨急性脑梗死患者颈动脉斑块内新生血管超声造影评价及其与血脂指标和超敏C反应蛋白水平的关系。方法：选取2018年6月到2019年6月期间我院收治的ACI患者186例，根据患者的颈动脉内中膜厚度（IMT）数值以及颈动脉斑块内新生血管超声造影情况将其分为无斑块组、稳定斑块组和易损斑块组。对比各组患者的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、美国国立卫生研究院卒中量表（NIHSS）评分、改良的Rankin评分（mRS）、超敏C反应蛋白（hs-CRP）水平。结果：易损斑块组和稳定斑块组患者的TC、LDL-C、TG、hs-CRP水平均明显高于无斑块组（P<0.05），易损斑块组患者的LDL-C、hs-CRP水平均明显高于稳定斑块组（P<0.05），易损斑块组和稳定斑块组患者的NIHSS评分和mRS评分均明显高于无斑块组（P<0.05），易损斑块组患者的NIHSS评分和mRS评分均明显高于稳定斑块组（P<0.05），经Pearson分析显示，LDL-C、hs-CRP、NIHSS评分和mRS评分与斑块分级均呈正相关（P<0.05）。结论：颈动脉斑块内新生血管超声造影技术可有效评估ACI患者的斑块稳定性，ACI患者的斑块分级与脂代谢紊乱、机体的炎症反应以及患者病情严重程度和预后均存在一定的相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the evaluation of neovascularization in carotid plaque of patients with acute cerebral infarction by contrast-enhanced ultrasound and its relationship with blood lipid index and high-sensitivity C-reactive protein levels. Methods: 186 patients with ACI who were admitted to our hospital from June 2018 to June 2019 were selected. According to the value of carotid intima-media thickness (IMT) and the condition of carotid plaque neovascularization, the patients were divided into plaque free group, stable plaque group and vulnerable plaque group. The total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C), national Institute of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS), high sensitive C-reactive protein (hs-CRP) in each group were compared. Results: The TC, LDL-C, TG and hs-CRP levels in vulnerable plaque group and stable plaque group were significantly higher than those in non plaque group(P<0.05). The LDL-C and hs-CRP levels in vulnerable plaque group were significantly higher than those in stable plaque group(P<0.05). The NIHSS and Mrs scores in vulnerable plaque group and stable plaque group were significantly higher than those in stable plaque group, the differences were statistically significant (P<0.05). The NIHSS score and Mrs score in the vulnerable plaque group were significantly higher than those in the stable plaque group (P<0.05). Pearson analysis showed that LDL-C, hs-CRP, NIHSS score and Mrs score were positively correlated with the plaque grade (P<0.05). Conclusion: The plaque stability of patients with ACI can be evaluated by contrast-enhanced ultrasound. The plaque classification of patients with ACI are related to the disorder of lipid metabolism, the inflammatory response of the body, the severity of the disease and the prognosis. |
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