| 缪 勇,冯 华,唐文静,张 玲,钟 璇.百令胶囊联合罗氟司特治疗老年支气管哮喘的效果及对免疫功能的影响[J].现代生物医学进展英文版,2021,(1):96-99. |
| 百令胶囊联合罗氟司特治疗老年支气管哮喘的效果及对免疫功能的影响 |
| Clinical Efficacy of Bailing Capsule Combined with Rofluoristone in the treatment of Elderly Patients with Bronchial Asthma and Its Effect on the Immune Function |
| Received:February 05, 2020 Revised:February 28, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.01.020 |
| 中文关键词: 百令胶囊 罗氟司特 老年支气管哮喘 免疫功能 |
| 英文关键词: Bailing Capsule Rofluorast Senile Asthma Immune Function |
| 基金项目:国家自然科学基金项目(81804165) |
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| 中文摘要: |
| 摘要 目的：研究百令胶囊联合罗氟司特治疗老年支气管哮喘的效果及对免疫功能的影响。方法：选择2018年3月～2019年3月我院第六派驻门诊部收治的110例老年支气管哮喘患者，随机分为两组，每组各55例。对照组患者口服罗氟司特片，每次500 mg，每天1 次。观察组患者联合服用百令胶囊，每次5粒，每天3次。比较两组的临床控制率，治疗前后两组诱导痰中炎症因子、中性粒细胞、呼出气一氧化氮(fractional exhaled nitric oxide，FeNO)水平和免疫功能的变化。结果：治疗后，观察组的临床控制率为70.91 %(39/55)，明显高于对照组[40.00 %(22/55)](P<0.05)；两组的CD4+、CD4+/CD8+和CD3+均较治疗前明显升高，且观察组的CD4+、CD4+/CD8+和CD3+明显高于对照组(P<0.05)；两组患者诱导痰中中性粒细胞绝对值、中性粒细胞百分比、白细胞介素-4(interleukin-4，IL-4)、FeNO、白细胞介素-17(interleukin-17，IL-17)均较治疗前明显降低(P<0.05)，诱导痰中的干扰素-γ(Interferon gamma，IFN-γ)均较治疗前明显升高(P<0.05)，且观察组诱导痰中的组中性粒细胞绝对值、中性粒细胞百分比、IL-4、FeNO、IL-17明显低于对照组(P<0.05)，诱导痰中的IFN-γ均明显高于对照组(P<0.05)。结论：百令胶囊联合罗氟司特对老年支气管哮喘患者具有显著的疗效，其机制可能与抑制中性粒细胞的激活、调节T淋巴细胞亚群的平衡和抑制相关炎症因子的释放相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of Bailing Capsule combined with rofluoristone in the treatment of elderly patients with bronchial asthma and its effect on immune function. Methods: Selected 110 elderly patients with bronchial asthma who were treated in our hospital from March 2018 to March 2019, divided into two groups randomly, each with 55 cases. The control group was treated with rofluoristone tablets orally, 500 mg each time, once a day. The observation group took bailing capsule, 5 capsules each time, 3 times a day. Compared the clinical control rate of the two groups, and observed the changes of inflammatory factors, neutrophils, exhaled FeNO level and immune function in the induced sputum of the two groups before and after treatment. Results: After treatment, the clinical control rate in the observation group was 70.91 % (39/55), which was significantly higher than the control group [40.00 % (22/55)] (P<0.05). After treatment, CD4 +, CD4 + / CD8 + and CD3 + in the two groups were significantly higher than before treatment, and the observation group were significantly higher than those in the control group (P<0.05). After treatment, the absolute value of neutrophils, percentage of neutrophils, IL-4, FeNO and IL-17 were significantly lower in the two groups than before treatment (P<0.05), and IFN-γ in the induced sputum was significantly higher than before treatment (P<0.05). The absolute value of neutrophils, the percentage of neutrophils, IL-4, FeNO and IL-17 in the induced sputum of the observation group were significantly lower than those of the control group (P<0.05), and the IFN-γ in the induced sputum was significantly higher than that of the control group (P<0.05). Conclusion: Bailing Capsule combined with rofluorostat had a significant effect on elderly patients with asthma. The mechanism may be related to the inhibition of neutrophil activation, the regulation of the balance of T-lymphocyte subsets and the inhibiting the release of related inflammatory factors. |
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