| 宋通微,杜 新,陈晓冰,李雄根,曹轶璇.MA诱导方案与DA诱导方案对老年急性髓系白血病患者血清炎症因子及复发率的影响[J].现代生物医学进展英文版,2021,(1):79-82. |
| MA诱导方案与DA诱导方案对老年急性髓系白血病患者血清炎症因子及复发率的影响 |
| The Effect of MA Induction and DA Induction on Inflammatory Factors and Recurrence Rate in Elderly Patients with Acute Myeloid Leukemia |
| Received:April 23, 2020 Revised:May 18, 2020 |
| DOI：10.13241/j.cnki.pmb.2021.01.016 |
| 中文关键词: 米托蒽醌 柔红霉素 老年 急性髓系白血病 炎症因子 复发率 |
| 英文关键词: Mitoxantrone Daunorubicin Elderly Acute myeloid leukemia Inflammatory factors Recurrence rate |
| 基金项目:广东省科技计划项目（2016A020216071） |
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| 中文摘要: |
| 摘要 目的：探讨米托蒽醌联合阿糖胞苷(MA方案)与柔红霉素联合阿糖胞苷(DA方案)对老年急性髓系白血病（AML）患者血清炎症因子及复发率的影响。方法：选取2015年1月~2018年1月期间深圳市人民医院收治的老年AML患者129例，根据治疗方案的不同将患者分为DA组（n=64，DA方案治疗）和MA组（n=65，MA方案治疗），比较两组患者疗效、炎症因子、不良反应及复发情况。结果：MA组治疗后的临床总有效率高于DA组（P<0.05）。两组患者治疗后血清干扰素 γ 诱导蛋白-10（IP-10）、巨噬细胞炎症蛋白-1α（MIP-1α）及可溶性细胞间黏附分子1（sICAM-1）水平均降低，且MA组低于DA组（P<0.05）。MA组完全缓解患者中累计复发率低于DA组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：与DA诱导方案相比，MA诱导方案治疗老年AML患者，可有效改善炎症因子水平，减少复发，且用药安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of mitoxantrone combined with cytarabine (MA) and daunorubicin combined with cytarabine (DA) on inflammatory factors and recurrence rate in elderly patients with acute myeloid leukemia (AML). Methods: 129 elderly AML patients who were admitted to Shenzhen People's Hospital from January 2015 to January 2018 were selected, the patients were divided into DA group (n=64, DA scheme treatment) and MA group (n=65, MA scheme treatment) according to different treatment schemes, the curative effect, inflammatory factors, adverse reactions and recurrence rate of the two groups were compared. Results: The total clinical effective rate of MA group was higher than that of DA group after treatment(P<0.05). The levels of IFN-γ - inducible protein-10 (IP-10), macrophage inflammatory protein-1α (MIP-1α) and soluble intercellular adhesion molecule-1 (sICAM-1) were all decreased of the two groups after treatment, and the level of MA group was lower than that of DA group (P<0.05). The cumulative recurrence rate in patients with complete remission of group MA was lower than that of group DA (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Compared with DA induction program, MA induction program can effectively improve the level of inflammatory factors and reduce the recurrence of elderly AML patients, and has better drug safety . |
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