| 张俊湖,张国荣,胡 铭,庞月玖,宋 进,张立攀.不同病情急性缺血性脑卒中患者血清过氧化还原蛋白1、钙调蛋白、触珠蛋白水平与预后的关系分析[J].现代生物医学进展英文版,2020,(24):4789-4792. |
| 不同病情急性缺血性脑卒中患者血清过氧化还原蛋白1、钙调蛋白、触珠蛋白水平与预后的关系分析 |
| Analysis of the Relationship between the Levels of Serum Peroxisome Reduction Protein 1, Calmodulin and Haptoglobin and Prognosis in Patients with Acute Ischemic Stroke |
| Received:June 30, 2020 Revised:July 26, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.24.043 |
| 中文关键词: 急性缺血性脑卒中 不同病情 血清过氧化还原蛋白1 钙调蛋白 触珠蛋白 预后 相关性 影响因素 |
| 英文关键词: Acute ischemic stroke Different conditions Serum peroxisome reduction protein 1 Calmodulin Haptoglobin Prognosis Correlation Influencing factors |
| 基金项目:山东省医药卫生科技发展计划项目（2017WS140） |
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| 中文摘要: |
| 摘要 目的：探讨不同病情急性缺血性脑卒中（AIS）患者血清过氧化还原蛋白1(PRDX1)、钙调蛋白(CAM)、触珠蛋白(HPT)水平与预后的关系。方法：收集2018年4月~2019年4月期间本院收治的127例AIS患者为研究对象，根据患者的病情分为轻度组(39例)、中度组(48例)、重度组(40例)，根据患者的改良Rankin 量表( mRS)评分将患者分为预后良好组(73例)和预后不良组(54例)，另选同期在我院进行健康检查的健康受试者50例为对照组。对比所有受试者PRDX1、CAM、HPT水平。对比不同预后患者的一般资料、PRDX1、CAM、HPT水平。分析PRDX1、CAM、HPT与NIHSS评分、mRS评分的关系。以多因素Logistic回归分析AIS患者预后的影响因素。结果：轻度组、中度组、中度组的PRDX1、CAM、HPT水平均高于对照组，且随着患者的病情加重，PRDX1、CAM、HPT水平依次升高，差异均有统计学意义(P<0.05)。预后不良组患者的年龄、PRDX1、CAM、HPT均高于预后良好组(P<0.05)。经Pearson检验，AIS患者的PRDX1、CAM、HPT与NIHSS、mRS评分均呈正相关(P<0.05)。经多因素Logistic回归分析可得，年龄较高、PRDX1水平升高、CAM水平升高、HPT水平升高是AIS患者预后不良的危险因素(P<0.05)。结论：AIS患者的PRDX1、CAM、HPT水平异常升高，且与其病情及预后呈现明显的相关性，年龄、PRDX1、CAM、HPT是患者预后的影响因素，对于病情的评估、预后的判断有一定的临床指导价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between the levels of serum peroxisome reduction protein 1 (PRDX1), calmodulin (CAM) and haptoglobin (HPT) and the prognosis of patients with acute ischemic stroke. Methods: 127 patients with acute ischemic stroke who were admitted to our hospital from April 2018 to April 2019 were selected as the research objects, According to their conditions, they were divided into mild group (39 cases), moderate group (48 cases), severe group (40 cases). Patients were divided into a group with good prognosis group (73 cases) and bad prognosis group (54 cases) according to modified Rankin Scale (mRS) score. Another 50 healthy subjects who were examined in our hospital at the same time were selected as the control group. The levels of PRDX1, CAM and HPT of all subjects were compared. The general data, the levels of PRDX1, CAM and HPT of patients with different prognosis were compared, the relationship between PRDX1, CAM, HPT and NIHSS score and mRS score were analyzed. The prognostic factors of patients with AIS were analyzed by multivariate Logistic regression. Results: The levels of PRDX1, CAM and HPT in the mild group, moderate group and moderate group were all higher than those in the control group, and the levels of PRDX1, CAM and HPT increased successively with the aggravation of the disease of the patients, with statistically significant differences (P<0.05). The age, PRDX1, CAM and HPT of patients in bad prognosis group were all higher than those in the good prognosis group (P<0.05). Pearson test showed that PRDX1, CAM, HPT, NIHSS and mRS scores of patients with AIS were positively correlated (P<0.05). Multiple Logistic regression analysis showed that higher age, higher PRDX1 level, higher CAM level, and higher HPT level were risk factors for poor prognosis of patients with AIS (P<0.05). Conclusion: The levels of PRDX1, CAM and HPT in patients with AIS are abnormally elevated, and they are significantly correlated with their condition and prognosis. Age, PRDX1, CAM and HPT were the influencing factors for the prognosis of patients, which had certain clinical guiding value for the evaluation of the condition and prognosis. |
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