| 刘 霞,沈 红,星学花,曹 静,沈银红,冶雪凤.百令胶囊联合吗替麦考酚酯对过敏性紫癜性肾炎患儿肾功能、体液免疫功能及血清炎性因子的影响[J].现代生物医学进展英文版,2020,(24):4756-4759. |
| 百令胶囊联合吗替麦考酚酯对过敏性紫癜性肾炎患儿肾功能、体液免疫功能及血清炎性因子的影响 |
| Effect of Bailing Capsule Combined with Mycophenolate Mofetil on Renal Function, Humoral Immune Function and Serum Inflammatory Factors in Children with Henoch Schonlein Purpura Nephritis |
| Received:July 07, 2020 Revised:July 30, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.24.035 |
| 中文关键词: 百令胶囊 吗替麦考酚酯 过敏性紫癜性肾炎 肾功能 体液免疫功能 炎性因子 |
| 英文关键词: Bailing capsule Mycophenolate mofetil Henoch Schonlein purpura nephritis Renal function Humoral immune function Inflammatory factors |
| 基金项目:青海省应用基础研究项目(2015-ZJ-730) |
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| 中文摘要: |
| 摘要 目的：探讨百令胶囊联合吗替麦考酚酯对过敏性紫癜性肾炎（HSPN）患儿肾功能、体液免疫功能及血清炎性因子的影响。方法：选取2014年7月~2020年2月期间我院收治的80例HSPN患儿，按照随机数字表法分为对照组（n=40，吗替麦考酚酯治疗）和观察组（n=40，百令胶囊联合吗替麦考酚酯治疗），对比两组疗效、肾功能[24 h尿蛋白定量（24 h Upro）、血肌酐（Scr）、尿素氮（BUN）]、体液免疫功能[免疫球蛋白(Ig)M、IgA、IgG]及血清炎性因子[γ-干扰素（IFN-γ）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）]，记录两组治疗期间不良反应情况。结果：与对照组相比，观察组的总有效率更高（P<0.05）。两组不良反应发生率对比未见差异（P>0.05）。治疗3个月后，两组Scr、24 h Upro、BUN、IgM、IgA、IgG、IFN-γ、IL-6、TNF-α均较治疗前下降，且观察组较对照组低（P<0.05）。结论：百令胶囊联合吗替麦考酚酯治疗HSPN患儿疗效值得肯定，可有效改善患儿肾功能、体液免疫功能，减轻患儿炎性反应，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Bailing capsule combined with mycophenolate mofetil on renal function, humoral immune function and serum inflammatory factors in children with Henoch Schonlein purpura nephritis (HSPN). Methods: 80 cases of children with HSPN in our hospital from July 2014 to February 2020 were selected, and divided into control group (n=40, treated with mycophenolate mofetil) and observation group (n=40, treated with Bailing capsule combined with mycophenolate mofetil) according to random number table method. The efficacy, renal function [24 h urinary protein quantification (24 h Upro), blood creatinine (Scr), urea nitrogen (BUN)], humoral immune function [immunoglobulin (Ig)M, IgA, IgG] and serum inflammatory factors [interferon-γ (IFN-γ), interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α)] were compared between the two groups. Adverse reactions during treatment in both groups were recorded. Results: Compared with the control group, the total effective rate of the observation group was higher (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). 3 months after treatment, Scr, Upro, BUN, IgM, IgA, IgG, IFN-γ, IL-6, TNF-α in the two groups decreased compared with those before treatment, and the observation group was lower than the control group (P<0.05). Conclusion: Bailing capsule combined with mycophenolate mofetil in the treatment of children with HSPN has a positive effect, which can effectively improve the renal function and humoral immune function, reduce the inflammatory reaction of children, and it has a good safety. |
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