| 郑艳妮,贺 芬,沙海旺,张 旭,袁伟伟.血必净注射液联合比阿培南对重症肺炎患者肺功能的影响[J].现代生物医学进展英文版,2020,(23):4561-4564. |
| 血必净注射液联合比阿培南对重症肺炎患者肺功能的影响 |
| Effect of Xuebijing Injection Combined with Biapenem on Pulmonary Function in Patients with Severe Pneumonia |
| Received:April 06, 2020 Revised:April 30, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.23.035 |
| 中文关键词: 血必净注射液 比阿培南 重症肺炎 炎症因子 应激激素 肺功能 |
| 英文关键词: Xuebijing injection Biapenem Severe pneumonia Inflammatory factor Stress hormone Lung function |
| 基金项目:国家自然科学基金项目（81760069）；陕西省社会发展科技攻关项目（2016SF-075） |
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| 中文摘要: |
| 摘要 目的：研究血必净注射液联合比阿培南对重症肺炎患者肺功能的影响。方法：选择2017年1月～2019年12月我院的103例重症肺炎患者，随机分为两组。对照组静脉滴注比阿培南0.3 g ，每 8 h给药1次；观察组联合静脉滴注血必净50 mL，每天两次。检测两组的炎症因子：白介素-1（Interleukin-1, IL-1）、肿瘤坏死因子-α（Tumor necrosis factor-α, TNF-α）和IL-6水平，应激激素：皮质醇（Cortisol, Cor）、人血管紧张素Ⅰ（Human angiotensin I, AngⅠ）、去甲肾上腺素（Noradrenaline, NE）和人血管紧张素Ⅱ（Human angiotensinⅡ, AngⅡ）水平，肺功能：第一秒最大呼气量（Maximum expiratory volume in the first second, FEV1）、FEV1%pred、用力肺活量（Forced vital capacity, FVC）。结果：观察组的有效率明显高于对照组（P<0.05）。治疗后，两组的血清IL-1、TNF-α、IL-6、Cor、AngⅠ、NE和AngⅡ水平水平均明显降低，FEV1、FEV1%pred和FEV1/FVC明显升高（P<0.05），且观察组的上述指标明显优于对照组（P<0.05）。结论：血必净注射液联合比阿培南对重症肺炎有显著的疗效，不但能明显改善肺功能，还能有效抑制患者的应激反应和炎症反应，值得推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Xuebijing injection combined with biapenem on pulmonary function in patients with severe pneumonia. Methods: Selected 103 cases of patients with severe pneumonia who were treated in our hospital from January 2017 to December 2019, divided into two groups randomly. The control group received 0.3 g of apenem once every 8 hours, while the observation group received 50 mL of Xuebijing twice a day. Detection of inflammatory factors in two groups: interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and IL-6 levels, stress hormone: Cortisol (Cor), human angiotensin I (Ang I), norepinephrine (NE) and human angiotensin II (Ang II) levels, lung function: maximum expiratory volume in the first second (FEV1), FEV1%pred, Forced vital capacity (FVC). Results: The effective rate of the observation group was significantly higher than control group (P<0.05). After treatment, the levels of serum IL-1, TNF-α, IL-6, Cor, AngⅠ, NE and AngⅡof the two groups were significantly reduced, and FEV1, FEV1%pred and FEV1/FVC were significantly increased (P<0.05), and the above indicators of the observation group were significantly better than the control group (P<0.05). Conclusion: Xuebijing injection combined with biapenem has a significant effect on severe pneumonia. It can not only improve the lung function, but also effectively inhibit the stress response and inflammatory response of patients. It is worth popularizing. |
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