| 干书文,曹引丽,席如如,亢 云,侯小霞.彩色多普勒超声检查对胎儿颅内畸形筛查的应用价值及染色体异常分析[J].现代生物医学进展英文版,2020,(22):4378-4381. |
| 彩色多普勒超声检查对胎儿颅内畸形筛查的应用价值及染色体异常分析 |
| Application of Color Doppler Ultrasonography in Screening Fetal Intracranial Malformation and Analysis of Chromosomal Abnormalities |
| Received:February 24, 2020 Revised:March 21, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.22.040 |
| 中文关键词: 彩色多普勒超声 胎儿 颅内畸形 染色体 |
| 英文关键词: Color Doppler ultrasound Fetus Intracranial malformation Chromosome |
| 基金项目:中国疾病预防控制中心妇幼保健中心科研项目(2019FYH009) |
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| 中文摘要: |
| 摘要 目的：探讨彩色多普勒超声检查对胎儿颅内畸形筛查的应用价值，并进行染色体异常分析。方法：选择2016年2月至2019年5月本院收治的进行胎儿颅内畸形筛查的高危孕妇120例，所有孕妇都给予彩色多普勒二维超声与三维超声筛查，对超声筛查异常者进行染色体异常分析，记录预后情况。结果：在120例孕妇中，二维超声诊断为胎儿颅内畸形12例，三维超声诊断为13例(预后都确诊为胎儿颅内畸形)。染色体核型筛查检出胎儿颅内畸形12例，其中21-三体综合征8例，18-三体综合征3例，13-三体综合征1例。确诊为胎儿颅内畸形的孕妇超声NT值都显著高于非胎儿颅内畸形孕妇，差异都有统计学意义(P<0.05)。孕妇选择终止妊娠10例，选择继续妊娠3例，继续妊娠3例胎儿都最终死亡。结论：产前彩色多普勒超声结合染色体核型在胎儿颅内畸形筛查中具有很高的价值，两者可互相补充，共同发挥诊断与预后评估价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of color Doppler ultrasonography on the screening of fetal intracranial malformation and to analyze chromosomal abnormalities. Methods: From February 2016 to May 2019, 120 cases of high-risk pregnant women who were screened for fetal intracranial malformation were enrolled in the hospital. All pregnant women were given color Doppler two-dimensional ultrasound and three-dimensional ultrasound screening, and the abnormalities were analyzed for chromosomal abnormalities and the prognosis were recorded. Results: In the 120 pregnant women, 2D ultrasound were diagnosed as 12 cases of fetal intracranial malformation, and 13 cases were diagnosed by three-dimensional ultrasound (prognosis were diagnosed as fetal intracranial malformation). Chromosome karyotype screening detected 12 cases of fetal intracranial malformation, include 8 cases of 21-trisomy syndrome, 3 cases of 18-trisomy syndrome, and 1 case of 13-trisomy syndrome. The ultrasound NT value of pregnant women diagnosed as fetal intracranial malformation were higher than that of non-fetal intracranial malformation, and compared the difference were statistically significant (P<0.05). The pregnant woman chose to terminate the pregnancy in 10 cases, choose to continue the pregnancy in 3 cases, and continue to conceive 3 cases of the fetus will eventually die. Conclusion: Prenatal color Doppler ultrasound combined with karyotype is of great value in the screening of fetal intracranial malformation. The two can complement each other and play a diagnostic and prognostic value together. |
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