| 李晓荣,项汉城,詹晓燕,林玉蓓,陆慧玲.急性失血患者中早期输注冷沉淀治疗对凝血功能的影响[J].现代生物医学进展英文版,2020,(22):4249-4252. |
| 急性失血患者中早期输注冷沉淀治疗对凝血功能的影响 |
| Effect of Early Infusion Cryoprecipitate on Blood Coagulation in Patients with Acute Blood Loss |
| Received:January 29, 2020 Revised:February 26, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.22.010 |
| 中文关键词: 急性失血者 早期输注冷沉淀 凝血功能 影响 |
| 英文关键词: Acute blood loss Early infusion cryoprecipitate Coagulation function Influence |
| 基金项目:国家自然科学基金项目（81804117） |
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| 中文摘要: |
| 摘要 目的：探讨急性失血患者中早期输注冷沉淀治疗对凝血功能的影响。方法：收集江苏省中医院（南京中医药大学附属医院）2015年9月-2019年8月收治的80例急性失血患者的临床资料，将患者按照住院号排序后取随机数字后分为研究组（40例）和对照组（40例），其中对照组给予常规输注血小板治疗，研究组给予早期输注冷沉淀凝血因子治疗，观察两组凝血功能变化及临床指标。结果：两组患者均顺利完成相应的输注治疗，无终端、退出、输注中死亡等异常情况。研究组治疗的总有效率显著高于对照组（P＜0.05）。两组患者输血前的凝血酶原时间（Prothrombin time，PT）、部分活化凝血酶时间（Activated partial thromboplastin time，APTT）、纤维蛋白原（Fibrinogen，Fbg)、血小板（blood platelet，PLT）、凝血酶时间（thrombin time，TT）水平组间差异无统计学意义（P>0.05）；输血24 h后两组患者的TT、PT、APTT均降低，Fbg、PLT水平升高，并且研究组的变化幅度大于对照组变化幅度（P＜0.05）。研究组患者的有效止血率、平均止血时间、24 h悬浮红细胞续用量与对照组相比，有显著差异（P＜0.05）。结论：急性失血患者中早期输注冷沉淀治疗可改善患者的凝血功能，起到较好止血效果，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of early infusion cryoprecipitate on blood coagulation in patients with acute blood loss. Methods: The clinical data of 80 patients with acute blood loss admitted from September 2016 to August 2019 in our hospital were collected. The patients were randomly divided into study group (40 cases) and control group (40 cases). In the control group, conventional infusion platelet therapy was given. The study group was given early infusion of cryoprecipitate factor, and the changes of coagulation function and clinical indicators were observed. Results: Two groups of patients successfully completed the corresponding infusion therapy, and there were no abnormalities such as terminal, withdrawal, and death during infusion. The total effective rate of treatment in the study group was significantly higher than that in the control group (P<0.05). There were no differences in the levels of TT, PT, APTT, Fbg and PLT between the two groups before blood transfusion(P>0.05). After 24 h of transfusion, the TT, PT and APTT of the two groups were decreased, and the levels of Fbg and PLT were decreased. The increase was greater in the study group than in the control group, and the difference was statistically significant(P<0.05). The effective hemostasis rate, mean hemostasis time, and 24-hour suspension of red blood cells in the study group were significantly different from those in the control group(P<0.05). Conclusion: Early infusion of cryoprecipitate in patients with acute blood loss can improve the coagulation function of patients and play a better hemostasis effect, which is worthy of clinical application. |
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