| 任 华,高永伟,高春燕,李亚梅,李元霞.rh-INFα2b治疗儿童毛细支气管炎的疗效及对免疫功能的调节作用[J].现代生物医学进展英文版,2020,(21):4191-4195. |
| rh-INFα2b治疗儿童毛细支气管炎的疗效及对免疫功能的调节作用 |
| Therapeutic Effect of rh-INFα2b on the Children with Bronchiolitis and Its Regulation of Immune Function |
| Received:May 29, 2020 Revised:June 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.21.043 |
| 中文关键词: 重组人干扰素α2b 毛细支气管炎 免疫调节 |
| 英文关键词: Recombinant human interferon alpha 2b Bronchiolitis Immunomodulatory effects |
| 基金项目:中华国际科学交流基金会科研项目(Z2018LSXB009) |
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| 中文摘要: |
| 摘要 目的：探讨重组人干扰素α2b(rh-INFα2b)治疗儿童毛细支气管炎的临床效果及对免疫功能的调节作用。方法：选取我院儿科收治的毛细支气管炎患儿134例作为研究对象，采用随机数字表法将其分为观察组和对照组，每组各67例。两组均给予基础治疗措施，观察组采用雾化rh-INFα2b治疗，疗程均为一周。对比两组治疗前后的咳嗽、喘息、哮鸣音、三凹征症状评分、外周血T淋巴细胞分布、血清白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)、白细胞介素-2(IL-2)水平的变化。结果：观察组治疗后的咳嗽、喘息、哮鸣音、三凹征症状评分均显著低于对照组(P<0.05)，CD3+、CD4+、CD4+/CD8+均明显高于对照组(P<0.05)，而CD8+测定值、血清IL-4、IFN-γ、IL-2水平均显著低于对照组(P<0.05)；治疗7d后，观察组的痊愈率53.73%、显效率32.84%、有效率11.94%、无效率1.49%，对照组的痊愈率37.31%、显效率38.81%、有效率19.40%、无效率4.48%，观察组的痊愈率显著优于对照组(P<0.05)。结论：雾化rh-INFα2b可显著提高儿童毛细支气管炎的临床疗效，增强其免疫功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of rh-INFα2b in the treatment of bronchiolitis in children and its regulating effect on immune function. Methods: A total of 134 children with bronchiolitis treated in our hospital's pediatric department were selected as research objects, and they were divided into the observation group and the control group by random number table method, with 67 cases in each group. Both groups were given conventional treatment, and the observation group was treated with nebulized rh-INFα2b for one week. The changes of cough, wheezing, wheezing, tricuspid symptom score, peripheral blood T lymphocyte distribution, serum IL-4, IFN-γ, and IL-2 levels were compared between the two groups before and after treatment. Results: The cough, wheezing, wheezing, and trident sign scores of the observation group after treatment were significantly lower than those of the control group (P <0.05), CD3+, CD4 +, CD4+ / CD8 + were significantly higher than the control group (P <0.05). The CD8+ measured value, serum IL-4, IFN-γ, IL-2 levels were significantly lower than the control group (P <0.05). After 7 days of treatment, the recovery rate of the observation group was 53.73%, the apparent efficiency was 32.84%, the effective rate was 11.94%, and the ineffective rate was 1.49%. The cure rate of the control group was 37.31%, the apparent efficiency was 38.81%, the effective rate was 19.40%, and the inefficiency was 4.48%. The recovery rate of observation group was better than that in the control group (P<0.05). Conclusion: Nebulizing rh-INFα2b can significantly improve the clinical efficacy of bronchiolitis in children and enhance its immune function. |
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