| 孔振兴,马 恺,韩 娜,高 雪,王金华.血清MMP-9、TIMP-1、TNF-α及IL-10在未足月胎膜早破而早产产妇中的表达及临床意义[J].现代生物医学进展英文版,2020,(21):4168-4171. |
| 血清MMP-9、TIMP-1、TNF-α及IL-10在未足月胎膜早破而早产产妇中的表达及临床意义 |
| The Expression and Clinical Significance of Serum MMP-9,TIMP-1, TNF-α and IL-10 in Premature Parturients with Preterm Premature Rupture of Membranes |
| Received:January 29, 2020 Revised:February 25, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.21.038 |
| 中文关键词: 基质金属蛋白酶-9 基质金属蛋白酶抑制因子-1 肿瘤坏死因子-α 白细胞介素-10 未足月胎膜早破而早产 早产 |
| 英文关键词: Matrix metalloproteinase-9 Tissue inhibitor of metalloproteinase-1 Tumor necrosis factor-α Interleukin-10 Preterm premature rupture of membranes Premature |
| 基金项目:陕西省社会发展科技攻关项目（2016SF-473） |
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| 中文摘要: |
| 摘要 目的：探讨基质金属蛋白酶-9（MMP-9）、基质金属蛋白酶抑制因子-1（TIMP-1）、肿瘤坏死因子-α（TNF-α）及白细胞介素-10（IL-10）在未足月胎膜早破而早产产妇血清中的表达及临床意义。方法：选择2016年5月-2017年9月期间本院收治的58例未足月胎膜早破而早产产妇作为研究组，另选择同期于本院行剖宫产手术的58例足月分娩产妇作为对照组。对比两组血清MMP-9、TIMP-1、TNF-α及IL-10水平，研究组根据胎膜胎盘病理检查结果分为合并绒毛膜羊膜炎亚组（n=30）、未合并绒毛膜羊膜炎亚组（n=28），比较两亚组血清MMP-9、TIMP-1、TNF-α及IL-10水平。记录研究组与对照组的妊娠结局。结果：研究组血清MMP-9和TNF-α水平高于对照组，而TIMP-1和IL-10水平低于对照组（均P<0.05）。合并绒毛膜羊膜炎亚组血清MMP-9、TNF-α水平较未合并绒毛膜羊膜炎亚组升高，TIMP-1和IL-10水平较未合并绒毛膜羊膜炎亚组降低（均P<0.05）。研究组剖宫产、产后出血、新生儿肺炎发生率均高于对照组，新生儿Apgar评分低于对照组（均P<0.05）。结论：未足月胎膜早破而早产产妇血清MMP-9和TNF-α水平异常升高，TIMP-1和IL-10水平异常降低，检测产妇血清MMP-9、TNF-α、IL-10及TIMP-1有助于未足月胎膜早破而早产的诊断，且能够明确产妇的感染状态。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expression and clinical significance of serum matrix metalloproteinase-9(MMP-9), tissue inhibitor of metalloproteinase-1(TIMP-1), tumor necrosis factor -α(TNF-α) and interleukin-10(IL-10) in premature parturients with preterm premature rupture of membranes. Methods: 58 cases of premature parturients with preterm premature rupture of membranes who were treated in our hospital from May 2016 to September 2017 were selected as the study group, 58 full-term parturients who underwent cesarean section in our hospital in the same period were selected as control group in addition. The serum levels of MMP-9, TIMP-1, TNF-α and IL-10 were compared between the two groups, the study group were divided into subgroup with chorioamnionitis(n=30) and subgroup without chorioamnionitis(n=28) according to the results of fetal membrane and placenta pathology, the serum levels of MMP-9, TIMP-1, TNF-α and IL-10 in both subgroups were compared. Pregnancy outcomes in the study group and control group were recorded. Results: The levels of serum MMP-9 and TNF-α in the study group were higher than those of the control group, while the level of TIMP-1 and IL-10 were lower than that of the control group(All P<0.05). The serum levels of MMP-9 and TNF-α in subgroup with chorioamnionitis were higher than those of subgroup without chorioamnionitis, the TIMP-1 and IL-10 level was lower than that of subgroup without chorioamnionitis(All P<0.05). The incidence of cesarean section, postpartum hemorrhage, neonatal pneumonia in the study group were all higher than those in the control group, the Apgar score of newborn was lower than that of the control group (All P<0.05). Conclusion: Abnormal elevation of serum MMP-9 and TNF-α in premature parturients with preterm premature rupture of membranes, TIMP-1 and IL-10 are abnormal drop, detect TIMP-1, MMP-9, TNF-α, IL-10 and TIMP-1 in maternal serum are beneficial to the diagnosis of premature rupture of membranes leading to premature delivery and it can clarify the maternal infection status. |
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