| 崔艳辉,范宏玲,武玉巧,梁 振,宋 越,吉王明.达英-35治疗多囊卵巢综合征合并不孕症的疗效及对患者血清FSH、LH、TOS、TAS水平的影响[J].现代生物医学进展英文版,2020,(21):4164-4167. |
| 达英-35治疗多囊卵巢综合征合并不孕症的疗效及对患者血清FSH、LH、TOS、TAS水平的影响 |
| Clinical Efficacy of Daying-35 in the Treatment of Polycystic Ovary Syndrome Complicated with Infertility and Its Effect on the Serum FSH, LH, TOS and TAS Levels |
| Received:December 28, 2019 Revised:January 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.21.037 |
| 中文关键词: 达英-35 多囊卵巢综合征 不孕症 |
| 英文关键词: Da Ying -35 Polycystic ovary syndrome Infertility |
| 基金项目:山西省科技攻关基金项目(002047) |
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| 中文摘要: |
| 摘要 目的：研究达英-35治疗多囊卵巢综合征合并不孕症的疗效及对患者血清卵泡刺激素(FSH)、促黄体生成素(LH)、总氧化态(TOS)、抗氧化态(TAS)水平的影响。方法：选取2015年8月至2016年7月我院收治的76例多囊卵巢综合征合并不孕症患者，根据随机数字法分为观察组和对照组，38例每组。对照组使用克罗米芬，观察组在此基础上加以达英-35。比较两组患者临床疗效，治疗前后血清FSH、LH、TOS、TAS水平、卵泡数、卵巢体积、体重指数的变化及不良反应的发生情况。结果：治疗后，观察组临床总有效率显著高于对照组[89.47%(34/38) vs. 60.53%(23/38)](P<0.05)；两组患者的血清FSH、LH、TOS水平、卵泡数、卵巢体积、体重指数明显减少较治疗前均显著降低(P<0.05)，而血清TAS水平较治疗前显著上升(P<0.05)，且观察组的血清FSH、LH、水平明显低于对照组(P<0.05)，而血清TAS水平显著高于对照组(P<0.05)。观察组和对照组的不良反应的发生率比较无明显差异(P>0.05)。结论：达英-35治疗多囊卵巢综合征合并不孕症患者能有效提高患者的临床疗效和改善其临床症状，且安全性高，这可能与其有效改善患者血清FSH、LH、TOS、TAS水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the application of DaYing-35 in the treatment of polycystic ovary syndrome with infertility and its effects on the serum follicle stimulating hormone (FSH), luteinizing hormone (LH), total oxidative state (TOS), antioxidant State (TAS) levels. Methods: 76 patients with polycystic ovary syndrome complicated with infertility were enrolled in our hospital from August 2015 to July 2016. According to the random number method, those patients were divided into the observation group and the ontrol group. The control group was given clomiphene, while the observation group was given DaYing-35 on this basis of control group. The changes of serum levels of FSH, LH, TOS, TAS, follicle count, ovarian volume, body mass index before and after treatment and the incidence of adverse reaction were compared between the two groups. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group [89.47% (34/38) vs. 60.53% (23/38)] (P<0.05). After treatment, the levels of FSH, LH, TOS, number of follicles, ovarian volume and body mass index of both groups were significantly decreased (P<0.05), and the levels of TAS, of both groups were significantly increased (P <0.05). Compared with the control group, the levels of FSH, LH, TOS, follicle count, ovarian volume and body mass index in the observation group were obviously lower (P<0.05), and the level of TAS was significantly higher (P<0.05). There was no significant difference in the adverse reaction rate between the two groups(P>0.05). Conclusion: Daying-35 can effectively enhance the clinical efficay and improve the clinical syptoms in the treatment of polycystic ovary syndrome complicated with infertility, it might be related to the improvement of serum FSH, LH, TOS, TAS levels. |
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