| 蒋丽华,陈欢雪,白 怡,吴 妍,赵丽萍.狼疮性肾炎患者血清sTM、KIM-1、sCD134水平的表达及临床意义[J].现代生物医学进展英文版,2020,(21):4121-4125. |
| 狼疮性肾炎患者血清sTM、KIM-1、sCD134水平的表达及临床意义 |
| The Expression and Clinical Significance of Serum STM, KIM-1 and sCD134 in Patients with Lupus Nephritis |
| Received:April 23, 2020 Revised:May 18, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.21.027 |
| 中文关键词: 狼疮性肾炎 可溶性血栓调节蛋白 肾损伤分子-1 可溶性CD134 临床意义 |
| 英文关键词: Lupus nephritis Soluble thrombomodulin Renal injury molecule-1 Soluble CD134 Clinical significance |
| 基金项目:国家自然科学基金面上项目（31571184）；辽宁省自然科学基金项目（2013022055） |
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| 中文摘要: |
| 摘要 目的：研究狼疮性肾炎（LN）患者血清可溶性血栓调节蛋白（sTM）、肾损伤分子-1（KIM-1）及可溶性CD134（sCD134）水平的表达及临床意义。方法：选择2016年12月至2018年12月我院收治的LN患者100例，根据系统性红斑狼疮疾病活动度指数(SLEDAI)将患者分为活动期组(SLEDAI≥10分)56例，非活动期组(SLEDAI<10分)44例。另取同期于我院接受体检的健康志愿者50例记为对照组。比较各组受试者的各项肾功能指标、血清sTM、KIM-1及sCD134水平，分析血清sTM、KIM-1及sCD134水平与肾功能指标的相关性。应用受试者工作特征（ROC）曲线分析血清sTM、KIM-1及sCD134水平在LN诊断中的能效。结果：活动期组血尿素氮（BUN）、血肌酐（Scr）以及红细胞沉降率（ESR）水平均高于非活动期组、对照组，且非活动期组BUN、Scr以及ESR水平均高于对照组（P＜0.05）。活动期组血清sTM、KIM-1及sCD134水平均高于非活动期组、对照组，且非活动期组血清sTM、KIM-1及sCD134水平均高于对照组（P＜0.05）。经Pearson相关性分析显示，LN患者血清sTM、KIM-1、sCD134水平与患者BUN、Scr、ESR水平呈正相关（P＜0.05）。ROC曲线分析显示，sTM最佳临界值为24.46 ng/mL，曲线下面积为0.823；KIM-1最佳临界值为8.27μg/L，曲线下面积为0.823；sCD134最佳临界值为15.25 ng/mL，曲线下面积为0.823。结论：LN患者血清sTM、KIM-1及sCD134水平与患者疾病活动程度密切相关，对LN具有很好的诊断效能，临床可能通过联合检测血清sTM、KIM-1及sCD134水平，为LN的诊断以及疾病活动程度提供评估参考。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expression and clinical significance of serum soluble thrombomodulin (STM), renal injury molecule-1 (KIM-1) and soluble CD134（sCD134）in patients with lupus nephritis (LN). Methods: 100 LN patients in our hospital from December 2016 to December 2018 were selected. According to the systemic lupus erythematosus disease activity index (SLEDAI), the patients were divided into active group (SLEDAI≥10 points) 56 cases, inactive group (SLEDAI<10 points) 44 cases. Another 50 healthy volunteers who received physical examination in our hospital in the same period were taken as the control group. The renal function indexes, serum levels of STM, KIM-1 and sCD134 were compared, and the correlation between serum levels of STM, KIM-1 and sCD134 and renal function indexes was analyzed. The energy efficiency of serum STM, KIM-1 and scd134 levels in LN diagnosis was analyzed by ROC curve. Results: The levels of Blood urea nitrogen (BUN), creatinine (SCR) and erythrocyte sedimentation rate (ESR) in the active group were higher than those in the inactive group and the control group (P < 0.05). The serum levels of STM, KIM-1 and sCD134 in the active group were higher than those in the inactive group and the control group, and the serum levels of STM, KIM-1 and scd134 in the inactive group were higher than those in the control group (P < 0.05). The Pearson correlation analysis showed that the serum levels of STM, KIM-1 and sCD134 were positively correlated with the levels of BUN, SCR and ESR (P < 0.05). ROC curve analysis shows that the best critical value of STM was 24.46 ng/mL, the area under the curve was 0.823; the best critical value of KIM-1 was 8.27 μg/L, the area under the curve was 0.823. The best critical value of sCD134 was 15.25 ng/mL, and the area under the curve was 0.823. Conclusion: The serum levels of STM, KIM-1 and sCD134 in LN patients are closely related to the disease activity, which has a good diagnostic effect on LN. The combined detection of serum levels of STM, KIM-1 and sCD134 may provide a reference for the diagnosis and disease activity of LN. |
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