| 周少珠,何炜蔓,程 贞,展 昆,叶子恒.血清钙结合蛋白S100A12、脂联素及IL-17与稳定期COPD患者严重程度及肺功能的相关性[J].现代生物医学进展英文版,2020,(21):4046-4050. |
| 血清钙结合蛋白S100A12、脂联素及IL-17与稳定期COPD患者严重程度及肺功能的相关性 |
| Relationship between Serum Calcium Binding Protein S100A12, Adiponectin, IL-17 and the Severity and Pulmonary Function of Patients with Stable COPD |
| Received:February 28, 2020 Revised:March 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.21.009 |
| 中文关键词: 慢性阻塞性肺疾病 钙结合蛋白S100A12 脂联素 白细胞介素-17 稳定期 |
| 英文关键词: Chronic obstructive pulmonary disease Calcium binding protein S100A12 Adiponectin Interleukin-17 Stable period |
| 基金项目:广东省科技计划项目（2017A020219207） |
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| 中文摘要: |
| 摘要 目的：探讨血清钙结合蛋白S100A12、脂联素及白细胞介素-17（Interleukin-17，IL-17）水平与稳定期慢性阻塞性肺疾病（COPD）病情严重程度和肺功能的关系。方法：选择稳定期COPD患者（稳定期COPD组）和健康体检者（对照组）各80例，稳定期COPD患者分为四级：I级轻度（22例），Ⅱ级中度（24例），Ⅲ级重度（19例），Ⅳ级极重度（15例）。使用肺功能仪对所有研究对象的肺功能进行检查，采用血气分析仪检测动脉血中的氧分压 (PaO2) 和二氧化碳分压 (PaCO2)，采用酶联免疫吸附试验检测血清中钙结合蛋白S100A12、脂联素和IL-17水平，采用 Pearson相关分析各指标之间的相关性。结果：稳定期COPD组肺功能[第一秒用力呼出气量容积占预计值百分比（FEV1%）和第一秒用力呼出气量容积/用力肺活量（FEV1/FVC%）]和PaO2显著低于对照组（P<0.05），并随着COPD严重程度增加而降低（P<0.05）；稳定期COPD组血清钙结合蛋白S100A12、脂联素、IL-17水平和PaCO2均高于对照组（P<0.05），并随COPD严重程度增加而升高（P <0.05）。Pearson相关分析显示：稳定期COPD患者血清钙结合蛋白S100A12、脂联素和IL-17水平与FEV1%、FEV1/FVC%和PaO2呈负相关（P<0.05），与PaCO2呈正相关（P<0.05）。结论：钙结合蛋白S100A12、脂联素和IL-17可能共同参与了稳定期COPD慢性炎症过程，引起气流受限，影响肺通气功能，可以辅助评估稳定期COPD病情的严重程度。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum calcium binding protein S100A12, adiponectin and interleukin-17 (IL-17) levels and the severity and pulmonary function of patients with stable chronic obstructive pulmonary disease (COPD). Methods: 80 stable COPD patients (stable COPD group) and 80 healthy people (control group) were selected respectively, the patients with stable COPD were divided into four grades: grade I mild (22 cases) and grade II moderate (24 cases), grade III severe (19 cases), grade IV extremely severe (15 cases). The lung function of all subjects was examined by using a pulmonary function test machine. The lung function of all subjects was examined by pulmonary function instrument, the partial pressure of oxygen (PaO2) and the partial pressure of carbon dioxide (PaCO2) in the arterial blood of all patients were detected by a blood gas analyzer. Serum calcium binding protein S100A12, adiponectin and IL-17 levels were measured by enzyme-linked immunosorbent assay. Pearson correlation analysis was used to analyze the correlation among indicators. Results: Pulmonary function [forced expiratory volume in the first second (FEV1%) and forced expiratory volume in the first second/forced vital capacity (FEV1/FVC%)] and PaO2 in stable COPD group was significantly lower than that in control group (P<0.05), and decreased with the severity of COPD (P<0.05). Serum calcium binding protein S100A12, adiponectin, IL-17 levels and PaCO2 in stable COPD group were higher than that in control group (P<0.05), and increased with severity of COPD (P<0.05). Pearson correlation analysis shows that: serum calcium binding protein S100A12, adiponectin and IL-17 were negatively correlated with FEV1%, FEV1/FVC% and PaO2 in patients with stable COPD (P<0.05), and were positively correlated with PaCO2 (P<0.05). Conclusion: Calcium binding protein S100A12, adiponectin and IL-17 may participate in the chronic inflammatory process of COPD in stable stage, cause airflow restriction and affect pulmonary ventilation function, which can help to assess the severity of stable COPD. |
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