| 万 璐,白春梅,葛郁平,李宁宁,周 娜,王颖轶.红色诺卡氏菌细胞壁骨架辅助治疗肿瘤作用的研究个例分析及文献复习[J].现代生物医学进展英文版,2020,(21):4042-4045. |
| 红色诺卡氏菌细胞壁骨架辅助治疗肿瘤作用的研究个例分析及文献复习 |
| Study on the Role of Nocardia Rubra Cell Wall Skeleton in Adjuvant Treatment of Tumors (Case Analysis) |
| Received:March 28, 2020 Revised:April 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.21.008 |
| 中文关键词: 红色诺卡氏菌细胞壁骨架 抗肿瘤 临床疗效 |
| 英文关键词: Nocardia rubra cell wall skeleton Antitumor Clinical efficacy |
| 基金项目:中国医学科学院青年基金项目 (2017320001) |
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| 中文摘要: |
| 摘要 目的：探究红色诺卡氏菌细胞壁骨架(Nocardia rubra cell wall skeleton, N-CWS)辅助治疗肿瘤作用的研究。方法：在北京协和医院肿瘤内科近5年收治的实体肿瘤患者中，选取愿意接受N-CWS辅助治疗的患者，皮下注射红色诺卡氏菌细胞壁骨架（商品名艾克佳），200～400 μg/次，每周2次，监测其肿瘤标志物血清癌胚抗原(serum carcinoembryonic antigen, CEA)、影像学及体力状况评分(eastern cooperative oncology group，ECOG评分)等变化，评估N-CWS疗效。结果：病例1加用N-CWS后CEA下降并保持低值4月左右，ECOG评分保持在0~1分。病例2加用N-CWS后CEA下降并维持稳定2月，ECOG 0~1分，患者自觉使用后体力较前好转。病例3在化疗6程后CEA保持最低，并保持稳定1个月。ECOG 保持在0~2分。病例1和病例2的CEA保持稳定的时间长于病例3，且ECOG评分保持低于病例3。结论：使用N-CWS辅助治疗肿瘤，患者CEA水平下降，体力状况改善，显著的改善了患者的症状。 |
| 英文摘要: |
| ABSTRACT Objective: Study on the role of Nocardia rubra cell wall skeleton (N-CWS) in adjuvant treatment of tumors. Methods: Among patients with solid tumors treated by the Department of Oncology, Peking Union Medical College Hospital in the past 5 years, patients who were willing to receive N-CWS adjuvant therapy were subcutaneously injected with Nocardia red cell wall skeleton (brand name Aikejia), 200～400 μg / time Twice a week, monitor the changes in tumor markers serum carcinoembryonic antigen (CEA), imaging and physical condition scores to evaluate the efficacy of N-CWS. Results: After the addition of N-CWS to Case 1, CEA decreased and remained low for about 4 months, and the ECOG score remained at 0 to 1. In case 2, CEA decreased and remained stable for two months after N-CWS was added, and ECOG was 0 to 1 point. The patient's physical strength improved after using the consciousness. The CEA of case 3 remained minimum after 6 cycles of chemotherapy and remained stable for 1 month. ECOG stays at 0 ~ 2 points. The CEA of cases 1 and 2 remained stable for higher than case 3, and the ECOG score remained lower than case 3. Conclusion: With the use of N-CWS as an adjuvant therapy for tumors, the CEA level of patients decreased, and the patient's physical condition improved, which significantly improved the patient's symptoms. |
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