| 刘 玲,张晶晶,张 娟,杨惠桐,韩晚军,柯亨特.用于可视化光治疗的Mn3O4@CuS纳米粒的制备研究[J].现代生物医学进展英文版,2020,(21):4025-4029. |
| 用于可视化光治疗的Mn3O4@CuS纳米粒的制备研究 |
| Studies on the Preparation of Mn3O4@CuS Core-Shell Nanoparticles for Imaging Guided Phototherapy |
| Received:February 28, 2020 Revised:March 24, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.21.005 |
| 中文关键词: 可视化光治疗 核壳型纳米粒 磁共振成像 |
| 英文关键词: Imaging guided phototherapy Core-shell nanoparticles Magnetic resonance imaging |
| 基金项目:国家自然科学基金项目（81871480）；江苏省大学生创新创业训练计划项目（201910285136Y） |
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| 中文摘要: |
| 摘要 目的：本研究旨在制备用于肿瘤可视化光治疗的多功能Mn3O4@CuS核壳型纳米粒，在磁共振成像的引导下，使用近红外光定点辐照，实现局部光热消融治疗。方法：（1）采用高温热解法制备油胺稳定的Mn3O4纳米粒，在其表面构建CuS壳层，并进行聚乙二醇修饰，得到分散于水相中的Mn3O4@CuS核壳型纳米粒。（2）通过透射电镜、紫外可见近红外吸收光谱等方法对该纳米粒进行理化性质表征，并研究其体外磁共振成像、光热升温等性能。结果：制备的水相分散的Mn3O4@CuS纳米粒，粒径均一且分散性较好，形态为近圆形，粒径为9.30±2.29 nm；紫外可见近红外吸收光谱图表明Mn3O4@CuS纳米粒在近红外区有较强吸收，最大吸收峰位于1100~1200 nm范围；磁共振成像分析结果可计算出Mn3O4@CuS纳米粒的纵向弛豫率r1为1.662 mM-1s-1，表明其具有较好的磁共振增强造影效果；光热升温曲线显示Mn3O4@CuS纳米粒可在785 nm近红外激光下升温至73.5 ℃，具备较好的光热治疗潜力。结论：本文成功制备出水相分散的Mn3O4@CuS核壳型纳米粒，具有良好的磁共振造影成像性能和光热升温效应，有望应用于磁共振成像引导下的肿瘤可视化光治疗。 |
| 英文摘要: |
| ABSTRACT Objective: Multifunctional Mn3O4@CuS core-shell nanoparticles were designed and prepared for imaging guided phototherapy of tumor, in order to achieve localized tumor photoablation with near infrared irradiation under the guidance of contrast enhanced magnetic resonance imaging (MRI). Methods: (1) Oleylamine-stabilized Mn3O4 nanoparticles were synthesized using thermal decomposition method, followed by surface coating of CuS nanoshell and PEGylation, resulting in water-soluble Mn3O4@CuS core-shell nanoparticles. (2) Transmission electron microscope (TEM) morphology, UV-vis-NIR absorption spectra, size distribution and other physical-chemical properties of Mn3O4@CuS core-shell nanoparticles were evaluated, as well as its performance in MRI contrast enhanced and photo-induced hyperthermia. Results: Mn3O4@CuS core-shell nanoparticles had uniform spherical morphology with average size of 9.30±2.29 nm, and UV-vis-NIR absorption spectra showed their obvious and strong absorption in the near infrared region with peak absorbance at the range of 1100~1200 nm; The longitudinal relaxation rate (r1) of Mn3O4@CuS nanoparticles was calculated to be 1.662 mM-1 s-1, indicating the potential to act as a T1 MRI contrast agent; The temperature of Mn3O4@CuS nanoparticle suspension can be heated up to 73.5 ℃ with 785 nm near infrared laser irradiation, showing great capability to achieve photo-induced hyperthermia. Conclusion: Water-soluble Mn3O4@CuS core-shell nanoparticles were successfully fabricated with preferable MRI contrast enhancement and great photothermal effect, which could be applied for MRI guided phototherapy of tumor. |
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