| 张 乐,董 宁,曹伟靖,田 莹,王晓敏.Vitapex糊剂与氢氧化钙糊剂根尖诱导术治疗年轻恒牙根管感染患儿的疗效比较研究[J].现代生物医学进展英文版,2020,(20):3973-3977. |
| Vitapex糊剂与氢氧化钙糊剂根尖诱导术治疗年轻恒牙根管感染患儿的疗效比较研究 |
| Comparative Study of Vitapex Paste and Calcium Hydroxide Paste in the Treatment of Root Canal Infection of Young Permanent Teeth |
| Received:May 21, 2020 Revised:June 17, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.20.038 |
| 中文关键词: Vitapex糊剂 氢氧化钙糊剂 年轻恒牙 根管感染 儿童 疗效 |
| 英文关键词: Vitapex paste Calcium hydroxide paste Young permanent teeth Root canal infection Children Effect |
| 基金项目:国家自然科学基金青年基金项目（31600627）；陕西省卫生健康委科研基金项目（2018A008） |
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| 中文摘要: |
| 摘要 目的：对比Vitapex糊剂与氢氧化钙糊剂根尖诱导术治疗年轻恒牙根管感染患儿的临床疗效。方法：选择2016年1月至2018年1月于我院进行诊治的年轻恒牙根管感染的120例患儿为研究对象，随机将其分为研究组（n=68）和对照组（n=52），研究组接受Vitapex糊剂进行根尖诱导术治疗，对照组接受氢氧化钙糊剂进行根尖诱导术治疗，评价两组治疗前和治疗后1个月根管治疗期间疼痛（EIP）程度、牙根尖孔直径、根尖闭合时间和检测龈沟液白细胞介素（IL）-1β、IL-8和肿瘤坏死因子（TNF）-α水平，分别于治疗后1个月、6个月、1 年和2 年对临床疗效进行评估。结果：治疗后1个月研究组EIP程度0级、Ⅰ级、Ⅱ级和Ⅲ级的改善程度均明显优于对照组（P＜0.05）。治疗后1个月研究组龈沟液中IL-1 β、IL-8、TNF-α水平以及根尖孔直径、根尖闭合时间均明显低于对照组（P＜0.05）。治疗后6个月、1年和2年研究组的有效率为97.06%（66/68）、97.06%（66/68）和95.59%（65/68），均明显高于对照组的82.69%（43/52）、80.77%（42/52）和76.92%（40/52）（P＜0.05）。结论：年轻恒牙根管感染患儿采用Vitapex糊剂进行根尖诱导术治疗的临床疗效优于氢氧化钙糊剂根尖诱导术，其可缓解患儿疼痛程度，降低龈沟液中IL-1 β、IL-8和TNF-α水平，促进根尖闭合，缩短根尖闭合时间。 |
| 英文摘要: |
| ABSTRACT Objective: To compare the effect of Vitapex paste and calcium hydroxide paste on the treatment of root canal infection in young permanent teeth. Methods: From January 2016 to January 2018, 120 patients with root canal infection in young permanent teeth were selected as the study object, they were randomly divided into study group (n=68) and control group (n=52). The study group received Vitapex paste for apical induction treatment, while the control group received calcium hydroxide paste for apical induction treatment. The inter-appointment pain(EIP) degree, apical pore diameter, apical closure time and the levels of interleukin (IL)-1β, IL-8 and tumor necrosis factor-α(TNF-α) in gingival crevicular fluid of the two groups were evaluated and measured before treatment and 1 month after treatment. The clinical efficacy was evaluated at before treatment, 1 month after treatment, 6 months after treatment, 1 year after treatment and 2 years after treatment. Results: 1 month after treatment, the improvement of EIP level 0, level I and level III of the study group were significantly better than those of the control group(P<0.05). The levels of IL-1β, IL-8, TNF-α in gingival crevicular fluid, apical pore diameter and apical closure time of the study group at 1 month after treatment were significantly lower than those of the control group (P<0.05). The effective rate of the study group at 6 months after treatment, 1 year after treatment and 2 years after treatment were 97.06% (66/68), 97.06% (66/68) and 95.59%(65/68), which were significantly higher than that of the control group 82.69% (43/52), 80.77% (42/52) and 76.92% (40/52)(P<0.05). Conclusion: The clinical effect of Vitapex paste in the treatment of patients with root canal infection in young permanent teeth is better than that of calcium hydroxide paste. It can alleviate the degree of pain, reduce the levels of IL-1 β, IL-8 and TNF-α in gingival crevicular fluid, promote apical closure, and shorten the time of apical closure. |
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