| 杨 芳,檀增桓,韦志坤,杨 力,王利娟,高 明.碘131联合胰岛素泵对2型糖尿病伴发甲亢患者炎性因子和甲状腺功能的影响[J].现代生物医学进展英文版,2020,(20):3951-3955. |
| 碘131联合胰岛素泵对2型糖尿病伴发甲亢患者炎性因子和甲状腺功能的影响 |
| Effects of Iodine 131 Combined with Insulin Pump on Inflammatory Factors and Thyroid Function in Patients with Type 2 Diabetes Mellitus Complicated with Hyperthyroidism |
| Received:December 23, 2019 Revised:January 18, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.20.033 |
| 中文关键词: 2型糖尿病 甲状腺功能亢进 碘131 胰岛素泵 炎性因子 甲状腺功能 |
| 英文关键词: Type 2 Diabetes Hyperthyroidism Iodine 131 Insulin Pump Inflammatory factors Hyroid function |
| 基金项目:河北省卫生和计划生育委员会基金项目（20181668） |
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| 中文摘要: |
| 摘要 目的：观察碘131联合胰岛素泵治疗2型糖尿病伴发甲亢患者的临床疗效。方法：选取2017年3月至2019年1月本院收治的2型糖尿病伴发甲亢患者110例，按随机数表法分为观察组（n=55）与对照组（n=55），观察组患者给予碘131联合胰岛素泵治疗，对照组患者给予甲巯咪唑联合胰岛素注射治疗。分别在治疗前后检测两组患者的血糖、血清炎性因子及甲状腺功能指标，比较两组患者临床有效率及不良反应发生率。结果：观察组临床有效率为92.73%，高于对照组的74.55%（P<0.05）。治疗后，两组患者空腹血糖、餐后2 h血糖、糖化血红蛋白均下降（P<0.05），血清肿瘤坏死因子-α（TNF-α）、C-反应蛋白（CRP）、白细胞介素（IL）-6、总三碘甲状腺原氨酸（TT3）、游离三碘甲状腺原氨酸（FT3）、总四碘甲状腺原氨酸（TT4）、游离四碘甲状腺原氨酸（FT4）水平均下降，且观察组低于对照组（P<0.05）；观察组总不良反应率为18.18%，低于对照组的58.18%（P<0.05）。结论：碘131联合胰岛素泵治疗2型糖尿病伴发甲亢安全有效，能够更好地改善患者的甲状腺功能，降低炎性因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical efficacy of iodine 131 combined with insulin pump in the treatment of type 2 diabetes mellitus with hyperthyroidism. Methods: 110 patients with type 2 diabetes mellitus complicated with hyperthyroidism treated in our hospital from March 2017 to January 2019 were selected, they were divided into observation group (n=55) and control group (n=55) by random number table method. The observation group were treated with iodine 131 combined with insulin pump, while the control group received thiamazole combined with insulin injection. The blood sugar, serum inflammatory factors and thyroid function were measured before and after treatment between the two groups. The clinical efficacy and incidence of adverse reactions were compared between the two groups. Results: The clinical effective rate of the observation group was 92.73%, higher than 74.55% of the control group (P<0.05). After treatment, the fasting blood glucose, 2 h postprandial blood glucose and glycosylated hemoglobin decreased in both groups (P<0.05). The levels of serum tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin (IL)-6, total triiodothyronine (TT3), free triiodothyronine (FT3), total tetraiodothyronine (TT4), free tetraiodothyronine (FT4) decreased, and those in the observation group were lower than those in the control group (P<0.05). The total adverse reaction rate of the observation group was 18.18%, lower than 58.18% of the control group (P<0.05). Conclusion: Iodine 131 combined with insulin pump in the treatment of type 2 diabetes mellitus with hyperthyroidism is safe and effective, it can better improve the thyroid function of patients, reduce the level of inflammatory factors. |
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