| 宋慧娟,沈 灏,粟幼嵩,王晓良,潘令仪.布南色林联合团体心理治疗慢性精神分裂症的疗效及对认知功能、社会功能和服药依从性的影响[J].现代生物医学进展英文版,2020,(20):3849-3852. |
| 布南色林联合团体心理治疗慢性精神分裂症的疗效及对认知功能、社会功能和服药依从性的影响 |
| Efficacy of Blonanserin Combined with Group Psychotherapy on Chronic Schizophrenia and Its Effects on Cognitive Function, Social Function and Drug Compliance |
| Received:May 07, 2020 Revised:May 30, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.20.010 |
| 中文关键词: 慢性精神分裂症 布南色林 团体心理治疗 疗效 认知功能 社会功能 服药依从性 |
| 英文关键词: Chronic schizophrenia Blonanserin Group psychotherapy Efficacy Cognitive function Social function Drug compliance |
| 基金项目:上海市科委中医引导项目（16401934800） |
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| 中文摘要: |
| 摘要 目的：探讨布南色林联合团体心理治疗慢性精神分裂症（SZ）的疗效，分析其对认知功能、社会功能和服药依从性的影响。方法：选取124例慢性SZ患者随机分为对照组和观察组，对照组口服布南色林治疗，观察组在对照组基础上加以团体心理治疗，疗程均为2个月。治疗后，采用阳性与阴性症状量表（PANSS）和临床疗效总评量表-疾病严重程度（CGI-SI）评估两组患者治疗后的疗效，采用威斯康星卡片分类测验（WCST）评估两组患者治疗前后的认知功能，采用个人和社会功能量表（PSP）评估两组患者治疗前后的社会功能，评定两组患者治疗后的服药依从性。结果：治疗后，两组患者PANSS阳性症状、阴性症状、一般精神病理评分以及总评分均低于治疗前，且观察组低于对照组（P＜0.05）；两组患者CGI-SI评分均低于治疗前，且观察组低于对照组（P＜0.05）；两组患者WCST总应答数评分均高于治疗前，且观察组高于对照组（P＜0.05）；两组患者PSP总评分均高于治疗前，且观察组高于对照组（P＜0.05）；观察组服药依从性优于对照组（P＜0.05）。结论：布南色林联合团体心理治疗较单一布南色林治疗慢性SZ的治疗效果更好，能更好地提高患者的认知功能、社会功能以及服药依从性，值得临床借鉴推广。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy of bunanserine combined with group psychotherapy on chronic schizophrenia (SZ), and analyze its effects on cognitive function, social function and drug compliance. Methods: 124 patients with chronic SZ were selected and randomly divided into control group and observation group, the control group were treated with bunanserine orally, the observation group were treated with group psychotherapy on the basis of the control group, the courses of treatment were both 2 months. After treatment, positive and negative symptom scale (PANSS) and clinical global impression - severity of illness (CGI-SI) were used to evaluate the efficacy of patients in the two groups after treatment, wisconsin card sorting test (WCST) was used to evaluate cognitive function of patients in the two groups before and after treatment, personal and social performance scale (PSP) was used to evaluate the social function of patients in the two groups before and after treatment, drug compliance of patients in the two groups was evaluated after treatment. Results: After treatment, the positive symptoms, negative symptoms, general psychopathology scores and total scores of PANSS of patients in the two groups were all lower than those of before treatment, and the observation group were lower than those of the control group (P<0.05). The scores of CGI-SI in the two groups were all lower than those of before treatment, and the observation group were lower than those of the control group (P<0.05). The scores of WCST total number of answers in the two groups were higher than those of before treatment, and the observation group were higher than those of the control group (P<0.05). The total scores of PSP in the two groups were higher than those of before treatment, and the observation group were higher than those of the control group (P<0.05). Drug compliance in the observation group was better than that of the control group (P<0.05). Conclusion: Blonanserin combined with group psychotherapy is better than single blonanserin therapy for chronic SZ, which can better improve the cognitive function, social function and drug compliance of patients, it's worthy of clinical reference and promotion. |
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