| 武学海,张树娜,张国华,张佩佩,李正平.复方玄驹胶囊联合枸橼酸氯米芬和维生素E治疗男性肾阳虚型不育症的临床研究[J].现代生物医学进展英文版,2020,(19):3784-3787. |
| 复方玄驹胶囊联合枸橼酸氯米芬和维生素E治疗男性肾阳虚型不育症的临床研究 |
| A Clinical Study on Compound Xuanju Capsule Combined with Clomiphene Citrate and Vitamin E in Treating Male Infertility Due to Kidney Yang Deficiency |
| Received:April 08, 2020 Revised:April 30, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.19.040 |
| 中文关键词: 男性肾阳虚型不育症 复方玄驹胶囊 枸橼酸氯米芬 维生素E |
| 英文关键词: Male infertility of kidney-yang deficiency type Compound Xuanju capsule Clomiphene citrate Vitamin E |
| 基金项目:国家自然科学基金项目（81060368） |
| Author Name | Affiliation | E-mail | | WU Xue-hai | Qinghai Red Cross Hospital Reproductive Center, Xining, Qinghai, 810000, China | xuehaiW12@163.com | | ZHANG Shu-na | Qinghai Red Cross Hospital Reproductive Center, Xining, Qinghai, 810000, China | | | ZHANG Guo-hua | Department of Hepatobiliary and Pancreatic Diseases, Affiliated Hospital of Qinghai University, Xining, Qinghai, 810016, China | | | ZHANG Pei-pei | Department of Oncology, Affiliated Hospital of Qinghai University, Xining, Qinghai, 810016, China | | | LI Zheng-ping | Department of Urology, the Fourth People's Hospital of Qinghai Province, Xining, Qinghai, 810000, China | |
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| 中文摘要: |
| 摘要 目的：探讨复方玄驹胶囊联合枸橼酸氯米芬和维生素E对男性肾阳虚型不育症的治疗效果。方法：选择2017年1月-2019年12月于我院就诊并辨证为肾阳虚型男性不育症患者120例，采用随机数字表法分为研究组和对照组。对照组58例患者给予枸椽酸氯米芬和维生素E治疗，研究组62例患者在此基础上加用复方玄驹胶囊，比较两组临床疗效、治疗前后精子形态正常率、精液量、精子密度、前向运动率、精子液化时间、睾酮(testosterone，T)、黄体生成激素(luteotropic hormone，LH)、卵泡刺激素(follicle stimulatin hormone，FSH)及雌二醇(17β-estrodiol，E2)水平的变化。结果：治疗后，研究组患者的总有效率为85.48 %，显著高于对照组(72.41 %，P＜0.05)。与治疗前相比，两组患者精子形态正常率、精液量、精子密度和前向运动率均显著升高，而精子液化时间明显缩短(P＜0.05)，研究组患者精子形态正常率、精液量、精子密度和前向运动率均显著高于对照组，而精子液化时间较对照组显著缩短(P＜0.05)。与治疗前相比，两组患者血清T、LH、FSH水平显著增加，E2水平无明显变化；与对照组相比，研究组血清LH水平显著增加(P＜0.05)，T和FSH水平无显著差异。结论：复方玄驹胶囊联合枸橼酸氯米芬和维生素E对男性肾阳虚型不育症患者有较好的疗效，可显著提高精子质量，改善患者生殖激素水平。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the therapeutic effect of compound Xuanju capsule combined with clomiphene citrate and vitamin E on male infertility due to kidney-yang deficiency. Methods: A total of 120 patients with male infertility with kidney-yang deficiency syndrome who were treated in our hospital from January 2017 to December 2019 were selected and divided into a research group and a control group by random number table method. 58 patients in the control group were treated with clomiphene citrate and vitamin E. In the study group, 62 patients were added with compound Xuanju capsules to compare the clinical efficacy, normal rate of sperm morphology, semen volume and sperm before and after treatment Changes in density, forward movement rate, sperm liquefaction time, T, LH, FSH and E2 levels. Results: After treatment, the total effective rate of patients in the study group was 85.48 %, significantly higher than of the control group (72.41%, P<0.05). Compared with before treatment, the sperm morphology normal rate, semen volume, perm density and forward movement rate of the two groups of patients also increased significantly, sperm density and forward movement rate of the two groups of patients were significantly increased, while the sperm liquefaction time was significantly shortened (P<0.05). The normal rate of sperm morphology, semen volume, sperm density and forward movement rate of the study group were significantly higher than the control group, while the sperm liquefaction time was significantly shorter than that in the control group (P<0.05). Compared with before treatment, the serum T, LH and FSH levels of the study group was significantly increased (P<0.05), and the T and FSH levels were not significant difference. Conclusion: Compound Xuanju Capsule combined with clomiphene citrate and vitamin E had a good effect on male patients with infertility, which can significantly improves sperm quality and improves reproductive hormone levels. |
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