| 刘中均,李 霞,段小云,易 松,温慧敏,尹小娟,郑金文.丹红注射液联合骨肽注射液辅助治疗骨质疏松性骨折的疗效及对患者炎症反应和骨代谢的影响[J].现代生物医学进展英文版,2020,(18):3549-3552. |
| 丹红注射液联合骨肽注射液辅助治疗骨质疏松性骨折的疗效及对患者炎症反应和骨代谢的影响 |
| Effect of Danhong Injection Combined with Osteopeptide Injection in the Treatment of Osteoporotic Fracture and Its Effect on Inflammatory Response and Bone Metabolism |
| Received:February 05, 2020 Revised:February 28, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.18.034 |
| 中文关键词: 丹红注射液 骨肽注射液 骨质疏松性骨折 疗效 炎症反应 |
| 英文关键词: Danhong injection Osteopeptide injection Osteoporotic fracture Therapeutic effect Inflammatory response |
| 基金项目:四川省干部保健委员会科研项目（2019-606） |
| Author Name | Affiliation | E-mail | | LIU Zhong-jun | Department of Pharmacy, Sichuan Orthopaedic Hospital, Chengdu, Sichuan, 610041, China | scsgkyy_yb@163.com | | LI Xia | Department of Pharmacy, Sichuan Orthopaedic Hospital, Chengdu, Sichuan, 610041, China | | | DUAN Xiao-yun | Department of Pharmacy, Sichuan Orthopaedic Hospital, Chengdu, Sichuan, 610041, China | | | YI Song | Department of Pharmacy, Sichuan Orthopaedic Hospital, Chengdu, Sichuan, 610041, China | | | WEN Hui-min | Department of Pharmacy, Sichuan Orthopaedic Hospital, Chengdu, Sichuan, 610041, China | | | YIN Xiao-juan | Department of Pharmacy, Sichuan Orthopaedic Hospital, Chengdu, Sichuan, 610041, China | | | ZHENG Jin-wen | Department of Orthopaedics, Sichuan Orthopaedic Hospital, Chengdu, Sichuan, 610041, China | |
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| 中文摘要: |
| 摘要 目的：探讨丹红注射液联合骨肽注射液辅助治疗骨质疏松性骨折的疗效及对患者炎症反应和骨代谢的影响。方法：于2016年8月~2019年12月期间选取131例骨质疏松性骨折患者，根据随机数字表法将其分为对照组（n=65，常规治疗）与研究组（n=66，丹红注射液联合骨肽注射液辅助治疗），比较两组疗效以及不良反应发生情况，比较两组炎症因子[白介素-6（IL-6）、C-反应蛋白（CRP）、以及肿瘤坏死因子（TNF-α）]水平以及骨代谢指标[骨碱性磷酸酶（BALP）、骨钙素（BGP）、Ⅰ型胶原羧基端交联肽（CTX-1）]水平。结果：研究组治疗6周后的临床总有效率为87.88%（58/66），高于对照组的72.31%（47/65）（P<0.05）。两组治疗6周后IL-6、CRP、CTX-1、TNF-α水平均下降，且研究组低于对照组（P<0.05）。两组患者不良反应发生情况比较无统计学差异（P>0.05）。两组治疗6周后BALP、BGP水平升高，且研究组高于对照组（P<0.05）。结论：骨质疏松性骨折患者给予骨肽注射液联合丹红注射液辅助治疗，可有效改善患者的炎症反应和骨代谢情况，疗效显著。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the therapeutic effect of Danhong injection combined with osteopeptide injection in the treatment of osteoporotic fracture and its effect on inflammatory response and bone metabolism. Methods: 131 patients with osteoporotic fracture were selected from August 2016 to December 2019, the patients were divided into control group (n=65, routine treatment) and study group (n=66, Danhong injection combined with osteopeptide injection) according to the method of random number table. The efficacy and adverse reactions were compared between the two groups, the Levels of inflammatory factors [interleukin-6 (IL-6), c-reactive protein (CRP), and tumor necrosis factor -α (TNF -α)] and bone metabolism indexes [bone alkaline phosphatase (BALP), osteocalcin (BGP), type I collagen carboxy terminal crosslinking peptide (CTX-1)] were compared between the two groups. Results: The total clinical effective rate of the study group was 87.88% (58/66), which was higher than 72.31% (47/65) of the control group (P<0.05). The levels of IL-6, CRP, CTX-1 and TNF-α in the two groups decreased after 6 weeks of treatment, and the level in the study group was lower than that in the control group (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). The BALP and BGP levels of the two groups were higher than those of the control group (P<0.05). Conclusion: Osteopeptide injection combined with Danhong injection can effectively improve the inflammatory response and bone metabolism of patients with osteoporotic fracture. |
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