| 刘 佳,朱爱华,吴艳杰,盛佳曦,邢兰访.血必净注射液联合静脉胰岛素泵入治疗糖尿病酮症酸中毒的效果及对氧化应激反应的影响[J].现代生物医学进展英文版,2020,(18):3545-3548. |
| 血必净注射液联合静脉胰岛素泵入治疗糖尿病酮症酸中毒的效果及对氧化应激反应的影响 |
| Curative Efficacy of Xuebijing Injection Combined with Intravenous Insulin Pump in the Treatment of Diabetic Ketoacidosis and Its Effects on the Oxidative Stress Response |
| Received:April 06, 2020 Revised:April 30, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.18.033 |
| 中文关键词: 血必净注射液 胰岛素泵 糖尿病酮症酸中毒 单核细胞趋化蛋白 |
| 英文关键词: Xuebijing injection Insulin pump Diabetic ketoacidosis Monocyte chemotactic proteins |
| 基金项目:河北省科学技术厅科技攻关项目(08276101D-48) |
| Author Name | Affiliation | E-mail | | LIU Jia | Emergency department of Tangshan people's Hospital, Tangshan, Hebei, 063000, China | qianxuefeng065@163.com | | ZHU Ai-hua | Emergency department of Tangshan people's Hospital, Tangshan, Hebei, 063000, China | | | WU Yan-jie | Emergency department of Tangshan people's Hospital, Tangshan, Hebei, 063000, China | | | SHENG Jia-xi | Department of Endocrinology, Affiliated Hospital of North China University of technology, Tangshan, Hebei, 063000, China | | | XING Lan-fang | Emergency department of Tangshan people's Hospital, Tangshan, Hebei, 063000, China | |
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| 中文摘要: |
| 摘要 目的：探讨血必净注射液联合静脉胰岛素泵入治疗糖尿病酮症酸中毒的效果及对氧化应激反应的影响。方法：选择2016年8月至2018年8月我院收治的糖尿病酮症酸中毒患者80例，根据随机数表法分为观察组(n=41)和对照组(n=39)。对照组给予胰岛素泵治疗，观察组在对照组的基础上采用血必净注射液治疗。比较两组患者的临床疗效、治疗前后单核细胞趋化蛋白(MCP)、空腹血糖(FBG)、餐后血糖(PBG)、丙二醛(MDA)、超氧化物歧化酶(SOD)、总抗氧化能力(TAC)水平的变化及临床症状改善时间。结果：治疗后，两组单核细胞趋化蛋白水平均较治疗前显著下降，且观察组明显低于对照组(P<0.05)。治疗后，观察组MDA低于对照组，SOD、TAC水平均显著高于对照组(P<0.05)；观察组血糖达标、尿酮体转阴、PH恢复时间及胰岛素用量均显著低于对照组(P<0.05)。结论：血必净注射液联合胰岛素泵治疗糖尿病酮症酸中毒患者的效果显著明显优于单用血必净治疗，可能与其有效提高机体的抗氧化能力有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative efficacy of Xuebijing injection combined with intravenous insulin pump in the treatment of Diabetic ketoacidosis and its effects on the oxidative stress response. Methods: 80 patients with diabetic ketoacidosis admitted to our hospital from August 2016 to August 2018 were selected and divided into the observation group (n=41) and the control group (n=39) according to the random number table method. The control group was treated with insulin pump and the observation group was treated with Xuebijing injection on the basis of control group. The changes of monocyte chemoattractant protein (MCP), fasting blood glucose (FBG), postpranational blood glucose (PBG), malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels before and after treatment and the improvement time of clinical symptoms were compared between the two groups. Results: After treatment, the MCP levels in both groups were significantly decreased compared with those before treatment, which was significantly lower in the observation group than that of the control group (P<0.05). After treatment, the MDA in the observation group was lower than that in the control group, and SOD and TAC levels were significantly higher than those in the control group (P<0.05). In the observation group, the blood glucose standard, urine ketone body negative, PH recovery time and insulin dosage were significantly lower than those in the control group (P<0.05). Conclusion: The therapeutic effect of Xuebijing injection combined with insulin pump on the patients with diabetic ketoacidosis was significantly better than that of xuebijing injection alone, which may be related to the effective improvement of the antioxidant capacity. |
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