| 周明锐,李 杰,路 峥,王 丽,赵国霞,朱姗姗.保妇康栓联合小剂量雌激素对老年阴道炎血清雌激素水平及生活质量的影响[J].现代生物医学进展英文版,2020,(18):3494-3497. |
| 保妇康栓联合小剂量雌激素对老年阴道炎血清雌激素水平及生活质量的影响 |
| Effect of Baofukang Suppository Combined with Low Dose Estrogen on Serum Hormone Level and Quality of Life in Elderly Vaginitis |
| Received:February 15, 2020 Revised:March 12, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.18.021 |
| 中文关键词: 保妇康栓 雌激素 老年阴道炎 生活质量 疗效 |
| 英文关键词: Baofukang suppository Estrogen Senile vaginitis Quality of life Curative effect |
| 基金项目:安徽省卫生计生委科研项目（2018SEYL0306） |
| Author Name | Affiliation | E-mail | | ZHOU Ming-rui | Department of Obstetrics and Gynecology, the Second People's Hospital of Anhui Province, Hefei, Anhui, 230011, China | zhoumingrr@126.com | | LI Jie | Department of Obstetrics and Gynecology, the Second People's Hospital of Anhui Province, Hefei, Anhui, 230011, China | | | LU Zheng | Department of Obstetrics and Gynecology, the Second People's Hospital of Anhui Province, Hefei, Anhui, 230011, China | | | WANG Li | Department of Obstetrics and Gynecology, the Second People's Hospital of Anhui Province, Hefei, Anhui, 230011, China | | | ZHAO Guo-xia | Department of Obstetrics and Gynecology, the Second People's Hospital of Anhui Province, Hefei, Anhui, 230011, China | | | ZHU Shan-shan | Department of Obstetrics and Gynecology, the Second People's Hospital of Anhui Province, Hefei, Anhui, 230011, China | |
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| 中文摘要: |
| 摘要 目的：探讨应用保妇康栓联合小剂量雌激素治疗老年阴道炎患者的临床疗效及其对血清雌激素水平和生活质量的影响。方法：选择我院于2017年1月-2019年3月收治的老年阴道炎患者96例，按随机数字表法将其分为研究组（n=48）与对照组（n=48）。对照组应用高锰酸钾进行冲洗消毒加已烯雌酚片治疗，研究组在此基础上应用保妇康栓治疗。观察两组治疗效果和治疗前后孕酮（P）、雌二醇（E2）、黄体生成激素（LH）及卵泡刺激素（FSH）变化以及SF-36生活质量量表评分变化。结果：研究组阴道分泌物异常、外阴瘙痒或灼热、阴道黏膜萎缩症状消失时间短于对照组，总有效率高于对照组（P<0.05）。治疗后两组患者血清雌激素水平与SF-36量表各子项评分均较治疗前有改善，且研究组P、LH及FSH水平低于对照组（P<0.05），SF-36量表中的总体健康、社会功能、生理功能、躯体疼痛、精神健康、活力评分高于对照组（P<0.05）。结论：在小剂量雌激素基础上联合保妇康栓治疗可有效提升老年阴道炎的临床有效率，改善患者的雌激素水平，快速缓解阴道分泌物异常、外阴瘙痒或灼热、阴道黏膜萎缩症状的同时还可提高患者的生活质量，疗效令人满意，具有较好的临床价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of Baofukang suppository combined with low dose estrogen in the treatment of senile vaginitis, and the effect on serum hormone level and quality of life. Methods: 96 cases of senile vaginitis admitted in our hospital from January 2017 to March 2019 were selected, which were divided into research group(n=48) and control group(n=48) according to the method of random number table. The control group was treated with potassium permanganate and diethylstilbestrol, and the research group was treated with Baofukang suppository. The therapeutic effect, progesterone (P), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and SF-36 quality of life were observed before and after treatment. Results: The disappearance time of abnormal vaginal secretion, pruritus or burning of vulva, atrophy of vaginal mucosa in the research group was shorter than that in the control group, and the total effective rate of the research group was higher than that of the control group (P<0.05). After treatment, the level of serum estrogen and the scores of SF-36 were improved, P, LH and FSH in the research group were significantly lower than those in the control group（P<0.05）, the scores of overall health, social function, physiological function, physical pain, mental health and vitality in SF-36 were higher than those in the control group (P<0.05). Conclusion: Combined with Baofukang suppository on the basis of small dose of estrogen, which can effectively improve the clinical efficiency of senile vaginitis, improve the estrogen level of patients, rapidly relieve the symptoms of abnormal vaginal secretion, pruritus or scorching of vulva, atrophy of vaginal mucosa, and improve the quality of life of patients. The curative effect is satisfactory and has better clinical value. |
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