| 宋美玥,石 岩,姜 磊,陈 璐,李 娟,焦宇飞.卵巢sertoli-leydig细胞瘤（SLCTs）伴网状结构及异源性成分的临床病理学分析[J].现代生物医学进展英文版,2020,(18):3439-3442. |
| 卵巢sertoli-leydig细胞瘤（SLCTs）伴网状结构及异源性成分的临床病理学分析 |
| Clinicopathological Analysis of Ovarian Sertoli-Leydig Cell Tumor(SLCTs) with Reticular Structure and Heterogenous Components |
| Received:March 06, 2020 Revised:March 30, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.18.008 |
| 中文关键词: 网状结构 异源性成分 Sertoli-Leydig细胞瘤 临床病理 |
| 英文关键词: Reticular structure Heterogenous component Sertoli-Leydig cell tumor Clinicopathology |
| 基金项目:黑龙江省卫生计生委科研项目（2017-084） |
| Author Name | Affiliation | E-mail | | SONG Mei-yue | The second hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China | 15114658755@163.com | | SHI Yan | The second hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China | | | JIANG Lei | The second hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China | | | CHEN Lu | The second hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China | | | LI Juan | The second hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China | | | JIAO Yu-fei | The second hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China | |
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| 中文摘要: |
| 摘要 目的：究卵巢sertoli-leydig细胞瘤（SLCTs）伴网状结构及异源性成分的病理学差异，为病理诊断及临床治疗提供依据。方法：收集哈医大二院2010年1月-2019年1月手术切除的病例，病理诊断为SLCTs伴网状结构及异源性成分的病例共4例，观察这4例肿瘤的临床病理学特征。结果：对纳入研究的4例伴网状结构及异源性成分的卵巢SLCTs患者的研究结果显示：1）.肿瘤均发生于单侧卵巢。2）.患者年龄较年轻，平均年龄21.7岁。3）.按照恶性肿瘤的病理分级：无高分化病例，中-低分化SLCTs 3例， 低分化SLCT 1例。4）.免疫组化结果显示：α-inhibin、Calretinin 、MelanA 、CK、Vimentin（+），细胞质着色，EMA、CD10、CD99 部分（+），细胞膜着色，ER、PR、WT-1部分（+），细胞核着色，且四例肿瘤α-inhibin均呈阳性。 5）. 2例患者术前，睾酮水平均升高，其中一例也伴有肿瘤标志物CA125升高，并于术后均下降至正常。6）.术后对其中两例患者采用BEP（博来霉素＋依托泊苷＋顺铂）进行联合化疗3个疗程。对这4例患者术后随访3～36个月，有一例复发。结论：伴网状结构及异源性成分的卵巢SLCTs十分罕见，对肿瘤的及时正确病理诊断对临床治疗、术后指导具有重要意义。 |
| 英文摘要: |
| ABSTRACT Objective: To study the pathological difference of ovarian SLCTs with reticular structure and heterogenous components, and to provide help for pathological diagnosis and clinical treatment. Methods: a total of 4 cases with SLCTs reticular structure and heterogenous components were collected from the second hospital of Harbin Medical University from January 2010 to January 2019. The clinicopathological characteristics of these 4 cases were observed. Results: 1. All occurred in unilateral ovary. 2. The average age of the patients was 21.7 years old. 3. According to the pathological classification of malignant tumors, there are no highly differentiated cases, 3 moderately to poorly differentiated SLCTS and 1 poorly differentiated SLCT. 4. Immunohistochemical results showed that α- inhibin, vimentin, calretinin, CK, Melania cytoplasm (+), CD10, CD99, EMA cell membrane (+), WT-1, ER, PR, Ki-67 cell nucleus (+), and α- inhibin was positive in four tumors. 5. The level of testosterone was increased in two patients before operation, and CA125 was also increased in one of them, and decreased to normal after operation. 6. NO.Four patient was treated with BEP (bleomycin + etoposide + cisplatin) combined with chemotherapy for three courses. The 4 patients were followed up for 3 to 36 months, and one case recurred. Conclusion: Ovarian SLCTS with reticular structure and heterogenous components are very rare. The correct pathological diagnosis of the tumor plays an important role in the clinical guidance of postoperative treatment. The factors of poor prognosis of this kind of tumor may be related to age and no endocrine performance. |
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