| 吴艳杰,刘 佳,朱爱华,安庆丽,金吉明,邢兰访,姚 涛.奥拉西坦联合高压氧治疗重度一氧化碳中毒的疗效及对血清LPA、H-FABP及认知功能的影响[J].现代生物医学进展英文版,2020,(17):3367-3370. |
| 奥拉西坦联合高压氧治疗重度一氧化碳中毒的疗效及对血清LPA、H-FABP及认知功能的影响 |
| Curative Efficacy of Olactam Combined with Hyperbaric Oxygenin Treatment of Severe Carbon Monoxide Poisoningand its Effects on Serum LPA, H-fabp and Cognitive Function |
| Received:March 21, 2020 Revised:April 18, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.17.038 |
| 中文关键词: 奥拉西坦 高压氧 重度一氧化碳中毒 溶血磷脂酸 心型脂肪酸结合蛋白 认知功能 |
| 英文关键词: Olathe Hyperbaric oxygen Severe carbon monoxide poisoning Lysophosphatidic acid Heart-type fatty acid binding protein Cognitive function |
| 基金项目:河北省自然科学基金项目(C2004000689) |
| Author Name | Affiliation | E-mail | | WU Yan-jie | Department of emergency medicine, Tangshan people's Hospital, Tangshan, Hebei, 063001, China | shenchuan6633@163.com | | LIU Jia | Department of emergency medicine, Tangshan people's Hospital, Tangshan, Hebei, 063001, China | | | ZHU Ai-hua | Department of emergency medicine, Tangshan people's Hospital, Tangshan, Hebei, 063001, China | | | AN Qing-li | Department of emergency medicine, Tangshan people's Hospital, Tangshan, Hebei, 063001, China | | | JIN Ji-ming | Department of general medicine, Tangshan people's Hospital, Tangshan, Hebei, 063001, China | | | XING Lan-fang | Department of general medicine, Tangshan people's Hospital, Tangshan, Hebei, 063001, China | | | YAO Tao | Emergency department of Affiliated Hospital of North China University of science and technology, Tangshan, Hebei, 063000, China | |
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| 中文摘要: |
| 摘要 目的：探讨奥拉西坦联合高压氧治疗重度一氧化碳中毒的疗效及对血清溶血磷脂酸（LPA）、心型脂肪酸结合蛋白（H-FABP）及认知功能的影响。方法：选择2016年1月-2018年1月我院收治的重度一氧化碳中毒患者90例进行研究，以随机数表法分为观察组（n=48）和对照组（n=42）。对照组给予高压氧治疗，观察组在对照组的基础上加用奥拉西坦治疗。比较两组患者的临床疗效、血清LPA、H-FABP、认知能力、住院时间、迟发性脑病发生率。结果：两组总有效率分别为93.75%、76.19%，差异显著（P＜0.05）；治疗前，两组血清LPA、H-FABP水平无显著性差异；治疗后，两组血清LPA、H-FABP均显著下降，且观察组血清LPA、H-FAB P水平低于对照组，（P＜0.05）；治疗前，两组患者认知功能无显著性差异；治疗后，两组认知功能较治疗前均显著升高（P＜0.05），且观察组定向力、记忆力、注意力、语言能力水平均明显高于对照组（P＜0.05）；观察组患者住院时间、迟发性脑病发生率均显著低于对照组，差异显著（P＜0.05）。结论：在重度一氧化碳中毒患者中应用奥拉西坦联合高压氧效果显著，可有效改善患者血清LPA、H-FABP水平及认知功能。 |
| 英文摘要: |
| ABSTRACT Objective: To study Curative efficacy of olactam combined with hyperbaric oxygenin treatment of Severe carbon monoxide poisoningand its effectsonserum lysophosphatidic acid (LPA), heart-type fatty acid binding protein (H-FABP) and cognitive function. Methods: 90 cases of severe carbon monoxide poisoning admitted to our hospital from January 2016 to January 2018 were selected for the study, divided into observation group(n=48) and control group(n=42) by random number table method. The control group was treated with hyperbaric oxygen, and the observation group was treated with olracitamon the basis of the control group. The clinical efficacy, serum LPA, h-fabp, cognitive ability, length of stay and incidence of delayed encephalopathy were compared between the two groups. Results: After treatment, the total effective rate of the two groups was 93.75% and 76.19%, respectively, with significant difference (P<0.05). Before treatment, there was no significant difference in serum LPA and h-fabp levels between the two groups. After treatment, serum LPA and h-fabp in both groups decreased significantly, and serum LPA and h-fab P levels in the observation group were lower than those in the control group (P<0.05). Before treatment, there was no significant difference in cognitive function between the two groups. After treatment, the cognitive functions of the two groups were significantly increased compared with those before treatment (P<0.05), and the levels of orientation, memory, attention and language ability in the observation group were significantly higher than those in the control group (P<0.05). The length of stay and the incidence of delayed encephalopathy in the observation group were significantly lower than those in the control group (P<0.05). Conclusion: Olracetam combined with hyperbaric oxygen has a significant effect in patients with severe carbon monoxide poisoning, and can effectively improve serum LPA, h-fabp levels and cognitive function. |
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