| 张 冬,孙英豪,高 剑,赵 飞,张 锦.血清RBP4、NGAL、Klotho蛋白在慢性肾脏病病情监测及预后评估中的价值[J].现代生物医学进展英文版,2020,(17):3358-3362. |
| 血清RBP4、NGAL、Klotho蛋白在慢性肾脏病病情监测及预后评估中的价值 |
| Serum Levels of RBP4, NGAL, Klotho in Monitoring of Chronic Kidney Disease and Their Roles in Prognosis Evaluation |
| Received:March 28, 2020 Revised:April 24, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.17.036 |
| 中文关键词: 慢性肾脏病 视黄醇结合蛋白4 中性粒细胞明胶酶相关脂质运载蛋白 Klotho蛋白 病情监测 预后 |
| 英文关键词: Chronic kidney disease Retinol binding protein 4 Neutrophil gelatinase-associated lipocalin Klotho protein Disease surveillance Prognosis |
| 基金项目:河北省沧州市科学技术研究与发展指导计划项目(1213021ZD)；河北省自然科学计划项目(H2014235045) |
| Author Name | Affiliation | E-mail | | ZHANG Dong | Department of Nephrology, Cangzhou Central Hospital, Cangzhou, Hebei, 061000, China | zlz0001003@163.com | | SUN Ying-hao | Department of Nephrology, Cangzhou Central Hospital, Cangzhou, Hebei, 061000, China | | | GAO Jian | Department of Nephrology, Cangzhou Central Hospital, Cangzhou, Hebei, 061000, China | | | ZHAO Fei | Department of Nephrology, Cangzhou Central Hospital, Cangzhou, Hebei, 061000, China | | | ZHANG Jin | Oriental Hospital, Beijing University of traditional Chinese medicine, Beijing, 100078, China | |
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| 中文摘要: |
| 摘要 目的：探讨血清视黄醇结合蛋白4（retinol binding protein 4，RBP4）、中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase-associated lipocalin，NGAL）、Klotho蛋白在慢性肾脏病病情监测及预后评估中的价值。方法：收集我院2017年5月~2019年2月收治的297例慢性肾脏病患者为研究对象，依据肾小球滤过率（GFR）分为1期24例、2期46例、3期128例、4期66例、5期33例，并依据临床转归情况分为肾功能稳定组104例和肾功能恶化组193例；同期选择门诊健康体检者251例作为对照组。比较各组血清RBP4、NGAL、Klotho蛋白表达情况，并分析慢性肾脏病患者血清RBP4、NGAL、Klotho蛋白和GFR的相关性。结果：慢性肾脏病组血清RBP4、NGAL水平高于对照组，Klotho蛋白低于慢性肾脏病组（P<0.05）。慢性肾脏病5期者血清RBP4、NGAL水平高于4期、3期、2期及1期者，Klotho蛋白低于4期、3期、2期及1期者，差异有统计学意义（P<0.05）。慢性肾脏病患者血清RBP4、NGAL和GFR呈负相关，Klotho蛋白和GFR呈正相关（P<0.05）。肾功能恶化组血清RBP4、NGAL水平高于肾功能稳定组，Klotho蛋白低于肾功能稳定组，差异有统计学意义（P<0.05）。结论：血清RBP4、NGAL及Klotho蛋白表达水平的变化对了解慢性肾脏病患者病情程度及预后评估中有重要的参考价值，建议临床予以重视。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the value of serum levels of retinol binding protein 4 (RBP4), neutrophil gelatinase-associated lipocalin (NGAL) and Klotho protein in monitoring of chronic kidney disease and their roles in prognosis evaluation. Methods: 297 patients with chronic kidney disease admitted to our hospital from May 2017 to February 2019 were collected as research objects. According to glomerular filtration rate (GFR), they were divided into 24 cases in phase 1, 46 cases in phase 2, 128 cases in phase 3, 66 cases in phase 4 and 33 cases in phase 5. According to clinical outcome, they were divided into 104 cases in stable renal function group and 193 cases in deteriorated renal function group. 251 healthy outpatients were selected as control group at the same time. The expressions of serum RBP4, NGAL and Klotho proteins in each group were compared, and the correlation between serum RBP4, NGAL, Klotho proteins and GFR in patients with chronic kidney disease was analyzed. Results: The levels of serum RBP4 and NGAL in CKD group were higher than those in control group, and the level of Klotho protein was lower than that in CKD group (P<0.05). The levels of serum RBP4 and NGAL in patients with chronic kidney disease stage 5 were higher than those in stages 4, 3, 2 and 1, while Klotho protein was lower than those in stages 4, 3, 2 and 1, the difference was statistically significant (P<0.05). The levels of serum RBP4, NGAL and GFR were negatively correlated, serum Klotho protein and GFR were positively correlated (P<0.05). The levels of serum RBP4 and NGAL in renal function deterioration group were higher than those in renal function stabilization group, and the level of Klotho protein was lower than those in renal function stabilization group, the difference was statistically significant (P<0.05). Conclusion: The changes of the levels of serum RBP4, NGAL and Klotho proteins have important reference values in understanding the severity and prognosis of chronic kidney disease patients, which should be paid attention to in clinical experiences. |
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