| 熊 伟,费润欢,周克湘,张 迁,李小燕.乙型肝炎肝硬化患者血清sICAM-1、IL-6、IL-18及TNF-α水平的表达及临床意义[J].现代生物医学进展英文版,2020,(17):3321-3324. |
| 乙型肝炎肝硬化患者血清sICAM-1、IL-6、IL-18及TNF-α水平的表达及临床意义 |
| Expression and Clinical Significance of Serum sICAM-1, IL-6, IL-18 and TNF-α in Patients with Hepatitis B and Cirrhosis |
| Received:November 26, 2019 Revised:December 21, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.17.027 |
| 中文关键词: 乙型肝炎 肝硬化 sICAM-1 IL-6 IL-18 TNF-α |
| 英文关键词: Hepatitis B Cirrhosis sICAM-1 IL-6 IL-18 TNF-α |
| 基金项目:重庆市教委科学技术研究项目（KJQN201701303） |
| Author Name | Affiliation | E-mail | | XIONG Wei | Department of Gastroenterology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China | 153536698@qq.com | | FEI Run-huan | Institute of Digestive Diseases of Whole Army, Southwest Hospital of Army Medical University, Chongqing, 400038, China | | | ZHOU Ke-xiang | Department of Gastroenterology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China | | | ZHANG Qian | Department of Gastroenterology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China | | | LI Xiao-yan | Department of Gastroenterology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China | |
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| 中文摘要: |
| 摘要 目的：检测乙型肝炎肝硬化患者血清可溶性细胞间黏附分子-1（sICAM-1）、白细胞介素-6（IL-6）、白细胞介素-18（IL-18）及肿瘤坏死因子-α（TNF-α）水平，并探讨其临床意义。方法：选取2017年1月至2019年6月我院收治的乙型肝炎肝硬化患者82例作为研究组，同期健康体检者80例作为对照组。比较研究组和对照组及不同Child-Pugh分级乙型肝炎肝硬化患者血清sICAM-1、IL-6、IL-18、TNF-α、肝功能指标血浆谷丙氨酸氨基转移酶（ALT）、白蛋白(ALB)水平，并分析各指标之间的相关性。结果：研究组血清sICAM-1、IL-6、IL-18、TNF-α和血浆ALT水平分别为（820.78±85.73）ng/mL、（41.71±13.24）ng/mL、（119.85±45.56）pg/mL、（52.23±22.24）ng/L、（155.20±56.27）U/L，显著高于对照组的（175.51±41.82）ng/mL、（6.67±2.23）ng/mL、（68.71±23.24）pg/mL、（5.65±1.28）ng/L、（15.65±5.23）U/L（P<0.05），血浆ALB水平显著低于对照组[（27.69±4.32）g/L vs（45.16±5.65）g/L]（P<0.05）。随Child-Pugh分级的升高，乙型肝炎肝硬化患者血清sICAM-1、IL-6、IL-18、TNF-α和血浆ALT水平逐渐升高，血浆ALB水平逐渐降低（P<0.05）。乙型肝炎肝硬化患者血清sICAM-1、IL-6、IL-18及TNF-?琢水平与血浆ALT水平呈正相关（P均<0.05），与血浆ALB水平呈负相关（P均<0.05），乙型肝炎肝硬化患者血清sICAM-1与IL-6、IL-18及TNF-α呈正相关（P均<0.05）。结论：乙型肝炎肝硬化患者血清sICAM-1、IL-6、IL-18、TNF-α水平异常升高，与Child-Pugh分级和肝功能有关，检测血清sICAM-1、IL-6、IL-18、TNF-α可能为乙型肝炎肝硬化的诊断和病情严重程度的判断提供依据。 |
| 英文摘要: |
| ABSTRACT Objective: To measured the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), interleukin-18 (IL-18) and tumor necrosis factor - α (TNF-α) in patients with hepatitis B and cirrhosis, and to explore their clinical significance. Methods: 82 patients with hepatitis B and cirrhosis who were admitted to our hospital from January 2017 to June 2019 were selected as the study group, and 80 healthy people in the same period as the control group. The levels of serum sICAM-1, IL-6, IL-18, TNF-α, ALT and ALB were compared between the study group and the control group, as well as the patients with different Child-Pugh grades of hepatitis B and cirrhosis, and the correlation between the indexes was analyzed. Results: The levels of sICAM-1, IL-6, IL-18, TNF-α and plasma ALT in the study group were （820.78±85.73）ng/mL, （41.71±13.24）ng/mL, （119.85±45.56）pg/mL, （52.23±22.24）ng/L, （155.20±56.27）U/L, which were significantly higher than （175.51±41.82）ng/mL, （6.67±2.23）ng/mL, （68.71±23.24）pg/mL, （5.65±1.28）ng/L, （15.65±5.23）U/L in the control group(P<0.05), and the levels of plasma ALB in the study group were significantly lower than those in the control group[（27.69±4.32）U/L vs（45.16±5.65）U/L](P<0.05). With the increase of Child-Pugh grade, the levels of serum sICAM-1, IL-6, IL-18, TNF-α and plasma ALT increased, and plasma ALB decreased(P<0.05). The levels of serum sICAM-1, IL-6, IL-18 and TNF-α in patients with hepatitis B and cirrhosis were positively correlated with plasma ALT(all P<0.05), negatively correlated with plasma ALB(all P<0.05). The levels of serum sICAM-1in patients with hepatitis B and cirrhosis were positively correlated with IL-6, IL-18 and TNF-α(P<0.05). Conclusion: The levels of sICAM-1, IL-6, IL-18 and TNF-α in serum of patients with hepatitis B and cirrhosis are increased abnormally, which are related to Child-Pug grade and liver function. The detection of serum sICAM-1, IL-6, IL-18 and TNF-α may provide a basis for the diagnosis of hepatitis B and cirrhosis and the judgment of the severity of the disease. |
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