| 秦文卿,张 慧,陈 刚,陈 明,姚玉前.难治性肺炎支原体肺炎患儿血清炎性细胞因子变化的临床意义及其危险因素分析[J].现代生物医学进展英文版,2020,(17):3301-3304. |
| 难治性肺炎支原体肺炎患儿血清炎性细胞因子变化的临床意义及其危险因素分析 |
| Clinical Significance of Changes in Serum Inflammatory Cytokines and Its Risk Factors in Children with Refractory Mycoplasma Pneumoniae Pneumonia |
| Received:March 28, 2020 Revised:April 23, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.17.022 |
| 中文关键词: 难治性肺炎支原体肺炎 普通肺炎支原体肺炎 炎性细胞因子 危险因素 |
| 英文关键词: Refractory mycoplasma pneumoniae pneumonia Common mycoplasma pneumoniae pneumonia Inflammatory cytokines Risk factors |
| 基金项目:国家科技攻关项目（2015BAI08B27）；江苏省医学创新团队项目（CXTDA2015128） |
| Author Name | Affiliation | | QIN Wen-qing | Department of Pediatrics, Lianyungang Hospital Affiliated to Xuzhou Medical University/The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu, 222002, China | | ZHANG Hui | Department of Pediatrics, Lianyungang Hospital Affiliated to Xuzhou Medical University/The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu, 222002, China | | CHEN Gang | Department of Pediatrics, Lianyungang Hospital Affiliated to Xuzhou Medical University/The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu, 222002, China | | CHEN Ming | Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China | | YAO Yu-qian | Department of Pediatrics, Lianyungang Hospital Affiliated to Xuzhou Medical University/The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu, 222002, China |
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| 中文摘要: |
| 摘要 目的：探讨难治性肺炎支原体肺炎（RMPP）患儿血清炎性细胞因子变化的临床意义及其危险因素。方法：将我院从2016年1月～2020年1月收治的72例RMPP患儿纳入研究，记作RMPP组。另取我院同期收治的普通肺炎支原体肺炎（MPP）患儿70例作为对照组。检测所有患儿的血清炎性细胞因子水平，并进行对比。此外，对比两组患儿各项基线资料，并以多因素Logistic回归分析RMPP发生的危险因素。另外，比较两组患儿的影像学特征。结果：RMPP组患儿血清白细胞介素-6（IL-6）以及白细胞介素-10（IL-10）水平均高于对照组（P＜0.05）；而两组肿瘤坏死因子-α（TNF-α）水平对比差异不明显（P＞0.05）。RMPP组年龄、发热持续时间、发热峰值、住院时间以及发热伴随症状人数占比均高于对照组（P＜0.05）。经多因素Logistic回归分析发现：发热持续时间、发热峰值、住院时间以及发热伴随症状均是RMPP患儿发病的危险因素（OR=2.773、2.344、1.058、2.515，均P＜0.05）。RMPP组大叶性肺炎、胸腔积液人数占比均高于对照组，而支气管肺炎人数占比低于对照组（P＜0.05）。结论：RMPP患儿血清IL-6以及IL-10水平均存在明显高表达，且发热持续时间、发热峰值、住院时间以及发热伴随症状均是RMPP发病的危险因素，临床工作中需要予以重视。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical significance of changes in serum inflammatory cytokines and its risk factors in children with refractory mycoplasma pneumoniae pneumonia (RMPP). Methods: 72 cases of children with RMPP who were admitted to our hospital from January 2016 to January 2020 were included in the study, which was referred to as RMPP group. In addition, 70 cases of common mycoplasma pneumoniae pneumonia (MPP) children who were admitted to our hospital at the same time were taken as the control group. Serum levels of inflammatory cytokines in all children were determined and to compared. In addition, the baseline data of the two groups were compared, and the risk factors of RMPP occurs were analyzed by multivariate Logistic regression. In addition, the imaging characteristics of the two groups were compared. Results: The serum levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) in the RMPP group were higher than those in the control group (P<0.05). However, there was no significant difference in the levels of tumor necrosis factor-α (TNF-α) between the two groups (P>0.05). Age, duration of fever, peak fever, hospital stays and the proportion of the number of people with fever accompanying symptoms in the RMPP group were all higher than those in the control group (P<0.05). Multivariate Logistic regression analysis showed that duration of fever, peak fever, hospital stays and associated symptoms of fever were all risk factors for the onset of RMPP (OR=2.773, 2.344, 1.058, 2.515, all P<0.05). The imaging characteristics of RMPP group were that the proportion of lobar pneumonia and pleural effusion were higher than those of the control group, while the proportion of bronchopneumonia was lower than that of the control group (P<0.05). Conclusion: Serum levels of IL-6 and IL-10 in children with RMPP are significantly high, duration of fever, peak fever, hospital stays and associated symptoms of fever are risk factors for the onset of RMPP, which should be paid attention to in clinical work. |
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