| 魏引廷,朱海冬,伏东宁,陈允旺,魏兰福.芪芍安胃胶囊/黄柴安胃胶囊治疗消化性溃疡伴HP感染的疗效及对胃蛋白酶原、胃泌素-17的影响[J].现代生物医学进展英文版,2020,(16):3185-3188. |
| 芪芍安胃胶囊/黄柴安胃胶囊治疗消化性溃疡伴HP感染的疗效及对胃蛋白酶原、胃泌素-17的影响 |
| The Curative Effect of Qishao Anwei Capsule / Huangchai Anwei Capsule Treat the Peptic Ulcer with HP Infection and its Influence on Pepsinogen and Gastrin-17 |
| Received:March 21, 2020 Revised:April 17, 2020 |
| DOI：10.13241/j.cnki.pmb.2020.16.041 |
| 中文关键词: 消化性溃疡 幽门螺杆菌 芪芍安胃胶囊 黄柴安胃胶囊 疗效 胃蛋白酶原 胃泌素-17 |
| 英文关键词: Peptic ulcer Helicobacter pylori Qishao Anwei capsule Huangchai Anwei capsule Curative effect Pepsinogen Gastrin-17 |
| 基金项目:国家自然科学基金项目(81603586)；连云港市卫生计生委科技项目（201611） |
| Author Name | Affiliation | E-mail | | WEI Yin-ting | Department of Spleen, Stomach, Liver and Gallbladder, Lianyungang Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Lianyungang, Jiangsu, 222004, China | lygzyy372@163.com | | ZHU Hai-dong | Department of Outpatient, Lianyungang Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Lianyungang, Jiangsu, 222004, China | | | FU Dong-ning | Department of Pharmaceutical, Lianyungang Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Lianyungang, Jiangsu, 222004, China | | | CHEN Yun-wang | Department of Spleen, Stomach, Liver and Gallbladder, Lianyungang Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Lianyungang, Jiangsu, 222004, China | | | WEI Lan-fu | Department of Gastroenterology, Jiangsu Integrated Traditional Chinese and Western Medicine Hospital, Nanjing, Jiangsu, 210028, China | |
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| 中文摘要: |
| 摘要 目的：探讨芪芍安胃胶囊/黄柴安胃胶囊用于治疗消化性溃疡伴幽门螺杆菌（HP）感染患者的疗效，分析其对血清胃蛋白酶原（PG）和胃泌素-17（G-17）的影响。方法：选取我院于2017年10月到2019年1月收治的消化性溃疡伴HP感染患者114例，分成观察组（n=57）和对照组（n=57）。给予对照组三联疗法，观察组在对照组的基础上予以芪芍安胃胶囊或黄柴安胃胶囊，疗程均为35 d。于治疗前后检测两组血清PGⅠ、PGⅡ、PGⅠ/ PGⅡ比值（PGR）和G-17水平。治疗后，两组行疗效评价，比较两组HP转阴率和1年内复发率，记录不良反应。结果：观察组总有效率94.74%，高于对照组总有效率82.46%（P<0.05）。观察组HP转阴率89.47%，高于对照组HP转阴率73.68%（P<0.05）。观察组1年内复发率11.11%，低于对照组1年内复发率27.66%（P<0.05）。观察组不良反应发生率低于对照组（P<0.05）。治疗后，两组血清PGⅠ、PGⅡ、G-17水平均低于治疗前，PGR高于治疗前，且观察组血清PGⅠ、PGⅡ、G-17水平均低于对照组，PGR高于对照组（P<0.05）。结论：芪芍安胃胶囊/黄柴安胃胶囊治疗消化性溃疡伴HP感染患者具有良好的临床疗效，能够提高HP转阴率，降低1年内复发率和不良反应，并改善血清PGⅠ、PGⅡ、PGR和G-17水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the curative effect of Qishao Anwei capsule / Huangchai Anwei capsule treat the patients with peptic ulcer and Helicobacter pylori (HP) infection, and to analyze its influence on serum pepsinogen (PG) and gastrin-17 (G-17). Methods: 114 cases patients with peptic ulcer and HP infection who were admitted to our hospital from October 2017 to January 2019 were selected, they were randomly divided into observation group（n=57）and control group（n=57）. The control group was given triple therapy, the observation group was given Qishao Anwei capsule or Huangchai Anwei capsule on the basis of the control group, the courses of treatment were all 35 d. The serum PGⅠ, PGⅡ, PGⅠ / PGⅡ ratio (PGR) and G-17 levels in the two groups were detected before and after treatment. After treatment, the curative effect of the two groups was evaluated, the HP negative conversion rate and recurrence rate within 1 year were compared between the two groups, the adverse reactions were recorded. Results: The total effective rate of observation group was 94.74%, which was higher than 82.46% of control group (P<0.05). The negative conversion rate of HP in the observation group was 89.47%, which was higher than 73.68% of the control group (P<0.05). The recurrence rate within 1 year in the observation group was 11.11%, which was lower than 27.66% in the control group (P<0.05). The incidence of adverse reactions in the observation group was lower than control group (P<0.05). After treatment, the serum PGⅠ, PGⅡ and G-17 levels in two groups were lower than those of before treatment, the PGR level was higher than that of before treatment, and the serum levels of PGⅠ, PGⅡ, G-17 of observation group were lower than the control group, the PGR level was higher than that of control group (P<0.05). Conclusion: Qishao Anwei capsul/Huangchai Anwei capsule treat the patients with peptic ulcer and HP have good clinical curative effect, can increase the negative conversion rate of HP, reduce the recurrence rate within 1 year and adverse reactions, and improve the serum levels of PGⅠ, PGⅡ, PGR and G-17. |
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