| 陈 涛,李向成,廉 彧,汲克强,华 军,马路遥.凝血功能对胸腔镜手术治疗非小细胞肺癌疗效评估及预后预测的临床价值分析[J].现代生物医学进展英文版,2020,(16):3082-3086. |
| 凝血功能对胸腔镜手术治疗非小细胞肺癌疗效评估及预后预测的临床价值分析 |
| Analysis of the Efficacy Evaluation and Prognostic Prediction Value of Coagulation Function for the Non-small Cell Lung Cancer Patients with Thoracoscopic Surgery |
| Received:December 07, 2019 Revised:December 31, 2019 |
| DOI：10.13241/j.cnki.pmb.2020.16.017 |
| 中文关键词: 胸腔镜手术 非小细胞肺癌 凝血功能 预后 |
| 英文关键词: Thoracoscopic surgery Non-small cell lung cancer Coagulation function Prognostic analysis |
| 基金项目:江苏省科技基金资助项目（BK20191069） |
| Author Name | Affiliation | E-mail | | CHEN Tao | Department of Thoracic Surgery, the affiliated Wuxi No.2 hospital of Nanjing Medical University, Wuxi, Jiangsu, 214002, China | ct67527@163.com | | LI Xiang-cheng | Department of Thoracic Surgery, the affiliated Wuxi No.2 hospital of Nanjing Medical University, Wuxi, Jiangsu, 214002, China | | | LIAN Yu | Department of Thoracic Surgery, the affiliated Wuxi No.2 hospital of Nanjing Medical University, Wuxi, Jiangsu, 214002, China | | | JI Ke-qiang | Department of Thoracic Surgery, the affiliated Wuxi No.2 hospital of Nanjing Medical University, Wuxi, Jiangsu, 214002, China | | | HUA Jun | Department of Thoracic Surgery, the affiliated Wuxi No.2 hospital of Nanjing Medical University, Wuxi, Jiangsu, 214002, China | | | MA Lu-yao | Cardiovascular surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 211166, China | |
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| 中文摘要: |
| 摘要 目的：探究凝血功能对胸腔镜手术治疗非小细胞肺癌的疗效评估及预后预测的临床应用价值。方法：选择在我院行胸腔镜手术治疗的50例非小细胞肺癌患者为研究对象，分析凝血功能指标与患者临床病理特征的关系，比较患者治疗前后凝血功能指标水平的变化，并对患者的预后进行预测。结果：不同性别、病理类型、病理期及淋巴结转移状态患者的凝血功能指标比较差异具有统计学意义(P<0.05)；患者行胸腔镜手术治疗后凝血功能指标水平变化显著(P<0.05)；Log-Rank单因素生存分析显示凝血功能指标中纤维蛋白原(Fib)和D-二聚体(D-D)水平高于平均值的非小细胞肺癌患者生存率显著降低(P<0.05)；Logistic多因素回归分析显示Fib和D-D升高为影响非小细胞肺癌患者生存期和预后的独立危险因素(P<0.05)。结论：凝血功能指标与胸腔镜手术治疗的非小细胞肺癌患者疗效及预后有一定的相关性，Fib和D-D是患者预后的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy evaluation and prognostic prediction value of Coagulation function for the non-small cell lung cancer patients with thoracoscopic surgery. Methods: 50 patients with non-small cell lung cancer who underwent thoracoscopic surgery in our hospital were selected as subjects. The relationship between coagulation function index and clinicopathological features was analyzed. The changes of coagulation function index before and after treatment were compared, and the prognosis of patients was evaluated. Results: Statistically significant differences were found in the coagulation function indexes between patients with different gender, pathological type, pathological stage and lymph node metastasis(P<0.05). The level of coagulation function was significantly changed after thoracoscopic surgery (P<0.05). Log-Rank one-way survival analysis showed that the survival rate of non-small cell lung cancer patients whose with fibrinogen (Fib) and D-dimer (DD) levels were higher than average was significantly lower (P<0.05). Logistic multivariate regression analysis showed that increased Fib and D-D were independent risk factors affecting the survival and prognosis of patients with non-small cell lung cancer(P<0.05). Conclusion: Coagulation function is correlated with the efficacy and prognosis of patients with non-small cell lung cancer treated by thoracoscopic surgery. Fib and D-D are independent risk factors for the prognosis of patients. |
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